JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB89254

Anti-CXCR2 antibody [MM0222-7J40]

Be the first to review this product! Submit a review

|

(2 Publications)

Mouse Monoclonal CXCR2 antibody. Carrier free. Suitable for Flow Cyt, WB, Neut and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCR2.

View Alternative Names

CD182, IL8RB, CXCR2, C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, CDw128b, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8 receptor type 2, IL-8R B

1 Images
Western blot - Anti-CXCR2 antibody [MM0222-7J40] (AB89254)
  • WB

Supplier Data

Western blot - Anti-CXCR2 antibody [MM0222-7J40] (AB89254)

All lanes:

Western blot - Anti-CXCR2 antibody [MM0222-7J40] (ab89254) at 1/500 dilution

All lanes:

Human placenta tissue lysate

Predicted band size: 40 kDa

Observed band size: 50 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0222-7J40

Isotype

IgG2a

Carrier free

Yes

Reacts with

Human

Applications

Neut, Flow Cyt, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CXCR2.

P25025

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "Neut" : {"fullname" : "Neutralising", "shortname":"Neut"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "Neut-species-checked": "guaranteed", "Neut-species-dilution-info": "", "Neut-species-notes": "<p></p>" } } }
style
left-column
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCR2 also called C-X-C chemokine receptor type 2 is a G protein-coupled receptor with a mass of approximately 53 kDa. It primarily binds to chemokines like CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL7 and CXCL8 (also known as IL-8). CXCR2 is expressed in a variety of cells but is found especially in neutrophils where it plays a role in mediating immune response. Additionally it shows expression in some epithelial and endothelial cells contributing to its specialized functions in various tissues.
Biological function summary

CXCR2 plays significant roles in mediating inflammatory responses and is part of the chemokine receptor family. It functions by promoting chemotaxis of neutrophils to sites of inflammation infection or injury. This receptor operates with other chemokine receptors in the recruitment and migration of different immune cells helping coordinate an effective immune response. CXCR2 does not function alone and often interacts with other cell surface receptors and signaling molecules during immune responses.

Pathways

CXCR2 contributes prominently to the chemokine signaling pathway and the inflammatory response pathway. It interacts closely with proteins like CXCR1 another chemokine receptor to perform its functions. These interactions can activate downstream signaling cascades involving MAPK and PI3K pathways which are important for various cellular responses like proliferation survival and migration.

CXCR2 has associations with inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis. In these conditions excessive activation or expression of CXCR2 can lead to pathological inflammation. CXCR2 coordinates with proteins like IL-8 contributing to the chemotaxis of inflammatory cells in affected tissues and this coordination often exacerbates the inflammatory process in these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed : 1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed : 8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
See full target information CXCR2
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 14:215 PubMed36973255

2023

HOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Shimiao Zhu,Zhao Yang,Zheng Zhang,Hongli Zhang,Songyang Li,Tao Wu,Xuanrong Chen,Jianing Guo,Aixiang Wang,Hao Tian,Jianpeng Yu,Changwen Zhang,Lei Su,Zhiqun Shang,Changyi Quan,Yuanjie Niu

Journal of neuro-oncology 153:33-42 PubMed33835371

2021

Dura promotes metastatic potential in prostate cancer through the CXCR2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Michael J Strong,Sabrina Rocco,Russell Taichman,Gregory A Clines,Nicholas J Szerlip
View all publications
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column

Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB61100

Anti-CXCR2 (phospho S347) antibody

primary-antibodies

cxcr2-phospho-s347-antibody-ab61100

0

(0 reviews)

Alternative Product
Primary Antibodies

AB225732

Anti-CXCR2 antibody [EPR22301-103]

primary-antibodies

cxcr2-antibody-epr22301-103-ab225732

5

(1 reviews)

Alternative Product
Primary Antibodies

AB245982

Anti-CXCR2 antibody [EPR22301-103] - BSA and Azide free

primary-antibodies

cxcr2-antibody-epr22301-103-bsa-and-azide-free-ab245982

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com