AB137134

Anti-CXCR6 antibody [EPR9086]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal CXCR6 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

CD186, BONZO, STRL33, TYMSTR, CXCR6, C-X-C chemokine receptor type 6, CXC-R6, CXCR-6, CDw186, G-protein coupled receptor STRL33, G-protein coupled receptor bonzo

1 Images

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Western blot - Anti-CXCR6 antibody [EPR9086] (AB137134)

All lanes:

Western blot - Anti-CXCR6 antibody [EPR9086] (ab137134) at 1/1000 dilution

Lane 1:

Human colon cancer lysate at 10 µg

Lane 2:

JAR lysate at 10 µg

Lane 3:

Human placenta lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 181 kDa,35 kDa,39 kDa,40 kDa

Observed band size: 150 kDa

false

Carrier free

Anti-CXCR6 antibody [EPR9086] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9086

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCR6 also known as CD186 or BONZO is a chemokine receptor that belongs to the larger family of G protein-coupled receptors. This receptor has a molecular weight of approximately 45 kDa. CXCR6 gets expressed on various leukocytes including T-cells and natural killer cells. This expression profiles CXCR6 as essential in the immune system where its occupation involves directing cell movement via chemotaxis a process integral for normal immune surveillance and inflammatory response.

Biological function summary

CXCR6 critically orchestrates the interactions between T-cells and antigen-presenting cells within tissues. By engaging its ligand CXCL16 CXCR6 helps mediate cell adhesion and migration. This receptor works as part of an immune complex influencing the migration and retention of immune cells at sites of inflammation. The presence of CXCR6 enhances tissue-specific homing which is vital for localized immune responses.

Pathways

CXCR6 plays a significant role in the chemokine signaling pathway. This pathway leads immune cells to sites of inflammation or infection. Moreover CXCR6 interacts closely with other chemokine receptors such as CCR5. These receptor interactions ensure efficient communication and coordination in cell trafficking across immune environments all of which are critical for proper immune function.

CXCR6 has a known association with diseases like HIV and certain forms of cancer. CXCR6 can act as a co-receptor for the entry of some HIV strains into cells linking it to viral pathogenesis. In the context of cancer CXCR6 and its ligand CXCL16 have connections with tumor cell migration and metastasis. The interaction of CXCR6 with proteins like CXCL16 creates a microenvironment that can either suppress or promote tumor progression depending on the context.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

See full target information CXCR6

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 8: PubMed40897470

2025

Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction.

Applications

Unspecified application

Species

Unspecified reactive species

Takanori Nakamura,Shigeyuki Nada,Masaki Matsumoto,Nuha Loling Othman,Hidetaka Kosako,Kazuki Ikeda,Naohiko Koshikawa,Junya Masumoto,Tatsuya Sawasaki,Mutsuhiro Takekawa,Takashi Suzuki,Masato Okada

Frontiers in immunology 15:1343805 PubMed39403387

2024

Unlocking the secrets of NPSLE: the role of dendritic cell-secreted CCL2 in blood-brain barrier disruption.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Wang,Guimin Zheng,Peiwen Wang,Xiuchuan Jia

Molecular medicine reports 23: PubMed33215222

2020

Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197.

Applications

Unspecified application

Species

Unspecified reactive species

Xuejing Han,Zheng Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CXCR6 antibody [EPR9086]

Western blot - Anti-CXCR6 antibody [EPR9086] (AB137134)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise