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AB69152

Anti-CXorf21 antibody

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(3 Publications )

Anti-CXorf21 antibody (ab69152) is a mouse polyclonal antibody detecting CXorf21 in Western Blot. Suitable for Human.

- Trusted since 2009

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TASL.

Q9HAI6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Product details

What is this antibody validated in?
Anti-CXorf21 antibody (ab69152) is a mouse polyclonal antibody and is validated for use in Western Blot (WB) in Human samples.

What is the molecular weight of CXorf21?
Anti-CXorf21 (ab69152) specifically detects a band for CXorf21 (UniProt: Q9HAI6) at a molecular weight of 34kDa.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: 91% Water, 8% Sodium chloride, 0.6% Disodium hydrogenorthophosphate, 0.2% Potassium chloride, 0.2% Potassium phosphate monobasic
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXorf21 also known as chromosome X open reading frame 21 is a protein encoded by the CXorf21 gene. This target has a molecular mass of approximately 38 kDa. CXorf21 is known to be expressed widely in human tissues with notable expression in immune-related tissues such as the spleen and peripheral blood leukocytes. It functions mechanistically in cellular processes through its role as an integral membrane protein although specific binding partners and exact cellular functions remain active areas of research.
Biological function summary

CXorf21 is involved in the modulation of immune responses. It participates in processes involving immune cell signaling and may act as a receptor or activator in immune pathways. Studies suggest that CXorf21 plays a role in the regulation of immune cell activation and cytokine production indicating its involvement in immune modulation. CXorf21 is not generally recognized as part of a larger protein complex yet it interacts with components of the innate immune system.

Pathways

CXorf21 actively contributes to immune response pathways. It has associations with Toll-like receptor signaling and the regulation of inflammatory response pathways. Through these pathways CXorf21 also interacts with proteins like MyD88 and NF-kB which are important components of the inflammatory response. These interactions suggest its role in modulating cellular responses to pathogens and inflammatory stimuli.

CXorf21 shows associations with autoimmune diseases such as lupus and rheumatoid arthritis. Research indicates that altered expression of CXorf21 might contribute to the pathogenesis of these conditions. In lupus for instance CXorf21 could be linked to an overactive immune response. Furthermore CXorf21 interactions with proteins like TLR7 known for its role in autoimmunity highlight its potential impact on disease processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed : 32433612). Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons (PubMed : 32433612). Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PubMed : 31001245).
See full target information TASL

Alternative Names

CXorf21, TASL, TLR adapter interacting with SLC15A4 on the lysosome
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:6627 PubMed37863913

2023

Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xudong Chen,Min Xie,Sensen Zhang,Marta Monguió-Tortajada,Jian Yin,Chang Liu,Youqi Zhang,Maeva Delacrétaz,Mingyue Song,Yixue Wang,Lin Dong,Qiang Ding,Boda Zhou,Xiaolin Tian,Haiteng Deng,Lina Xu,Xiaohui Liu,Zi Yang,Qing Chang,Jie Na,Wenwen Zeng,Giulio Superti-Furga,Manuele Rebsamen,Maojun Yang

Aging cell 22:e13954 PubMed37614052

2023

Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Oleinik,Onder Albayram,Mohamed Faisal Kassir,F Cansu Atilgan,Chase Walton,Eda Karakaya,John Kurtz,Alexander Alekseyenko,Habeeb Alsudani,Megan Sheridan,Zdzislaw M Szulc,Besim Ogretmen

Journal of inflammation research 15:6607-6616 PubMed36510495

2022

miR-31-5p Regulates Type I Interferon by Targeting SLC15A4 in Plasmacytoid Dendritic Cells of Systemic Lupus Erythematosus.

Applications

Unspecified application

Species

Unspecified reactive species

Shifei Li,Qijun Wu,Zhuyan Jiang,Yaguang Wu,Yuhong Li,Bing Ni,Jun Xiao,Zhifang Zhai
View all publications
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Product promise

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