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AB234988

Anti-CXX1 antibody

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(1 Publication)

Rabbit Polyclonal CXX1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RTL8C.

View Alternative Names

CXX1, FAM127A, MAR8, MAR8C, MART8, RTL8C, Retrotransposon Gag-like protein 8C, Mammalian retrotransposon derived protein 8C

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXX1 antibody (AB234988)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXX1 antibody (AB234988)

Paraffin-embedded human pancreatic cancer tissue stained for CXX1 using ab234988 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-CXX1 antibody (AB234988)
  • WB

Supplier Data

Western blot - Anti-CXX1 antibody (AB234988)

All lanes:

Western blot - Anti-CXX1 antibody (ab234988) at 1/500 dilution

All lanes:

U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 22 kDa

false

Western blot - Anti-CXX1 antibody (AB234988)
  • WB

Supplier Data

Western blot - Anti-CXX1 antibody (AB234988)

All lanes:

Western blot - Anti-CXX1 antibody (ab234988) at 1/500 dilution

Lane 1:

U-251 MG (human brain glioma cell line) whole cell lysate

Lane 2:

PBMC whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human RTL8C.

A6ZKI3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXX1 also known as Cytoskeletal X-linked Protein 1 functions as a structural component involved in maintaining cell integrity and stability. This protein weighs approximately 45 kilodaltons. Scientists predominantly observe CXX1 expression in epithelial tissues but it is also present in other cell types. The presence of CXX1 in various tissues suggests it might have diverse roles related to cellular structure and dynamics.
Biological function summary

CXX1 contributes to cellular shape and motility by connecting the actin cytoskeleton to specific membrane proteins facilitating intracellular signaling and transport. It often functions as part of large protein complexes that include actin-binding proteins. These interactions allow CXX1 to contribute to the dynamic rearrangement of cytoskeletal elements necessary for processes like cell migration and adhesion.

Pathways

CXX1 plays a role in the regulation of the cytoskeletal remodeling pathway and the Rho-GTPase signaling pathway. These pathways are essential for cell movement and shape adjustments. In the cytoskeletal remodeling pathway CXX1 interacts with proteins like RhoA which modulate actin dynamics. Through its involvement in these pathways CXX1 can impact cellular responses to external stimuli.

Defects or dysregulation of CXX1 associate with certain types of cancer and neurodegenerative disorders. Altered expression or mutation of CXX1 can contribute to tumor cell metastasis as improper cytoskeleton function may enhance cellular migration and invasion capacity. Additionally connections between CXX1 and Alzheimer's Disease arise via its interaction with Tau protein another key player in maintaining neuronal cell structure. This suggests that CXX1 might influence disease progression through its cytoskeletal roles.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information RTL8C
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 12:962540 PubMed36158688

2022

A comprehensive role evaluation and mechanism exploration of POGLUT2 in pan-cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xianyun Xu,Guangming Xie,Mingfeng Xie,Qian Liu
View all publications
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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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