Rabbit Polyclonal CXXC5 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CXXC5.
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Publications
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- Cells 12:2023CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYeong Chan Ryu,Jiyeon Park,You-Rin Kim,Sehee Choi,Geon-Uk Kim,Eunhwan Kim,Yumi Hwang,Heejene Kim,Gyoonhee Han,Soung-Hoon Lee,Kang-Yell ChoiPubMed 36831222
- Scientific reports 6:378082016Estradiol-Estrogen Receptor α Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28:615-262013CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation.Applications:WBReactive species:MouseHyun-Yi Kim,Dong-Hwa Yang,Song-Weon Shin,Mi-Yeon Kim,Jae-Hyun Yoon,Suhyun Kim,Hae-Chul Park,Dong Woo Kang,Dosik Min,Man-Wook Hur,Kang-Yell ChoiPubMed 24136587
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human CXXC5. The exact immunogen used to generate this antibody is proprietary information. Database link Q7LFL8
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes Isoform 2 predicted molecular weight 24 kDa |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2.5 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
Associated Products
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Target data
Function
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034).
Alternative names
HSPC195, TCCCIA00297, CXXC5, CXXC-type zinc finger protein 5, CF5, Putative MAPK-activating protein PM08, Putative NF-kappa-B-activating protein 102, Retinoid-inducible nuclear factor, RINF
Recommended products
Rabbit Polyclonal CXXC5 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CXXC5.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human CXXC5. The exact immunogen used to generate this antibody is proprietary information. Database link Q7LFL8
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 12 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
Predicted to not cross-react with other CXXC protein family members.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CXXC5 also known as CXXC finger protein 5 is a DNA-binding protein with a molecular weight of approximately 35 kDa. This protein is expressed in various tissues including the brain and bone marrow. It functions mechanically by binding to unmethylated CpG dinucleotides influencing gene expression by affecting chromatin structure. Due to its DNA-binding ability CXXC5 can regulate transcription impacting various cellular processes.
- Biological function summary
CXXC5 plays a role in the regulation of Wnt/β-catenin signaling pathway and is involved in controlling cellular proliferation and differentiation. It does not form part of a larger protein complex but it interacts with other proteins to exert its function. CXXC5 can act as a transcriptional regulator by recruiting other proteins to modify epigenetic marks and modulates pathways critical for development and disease.
- Pathways
CXXC5 is involved in the Wnt/β-catenin signaling cascade a major pathway that regulates cell fate decisions migration and organogenesis. This protein bears relation to other pathway components such as β-catenin by interacting with them to convey signaling outcomes during cellular processes. In the bone it influences osteoblastic differentiation and bone formation making it an important component in skeletal development.
- Associated diseases and disorders
CXXC5 has been linked to conditions such as osteoporosis and certain types of cancer. In osteoporosis the altered function of CXXC5 affects bone density due to its role in bone anabolic responses with interactions with β-catenin being important. In cancer disruptions in CXXC5 expression or function can lead to uncontrolled cell proliferation and it is often examined in relation to tumor suppressor pathways highlighting its role in cellular growth control mechanisms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Western blot - Anti-CXXC5 antibody (ab106533)
All lanes: Western blot - Anti-CXXC5 antibody (ab106533) at 1 µg/mL
All lanes: human brain tissue lysate at 15 µg/mL
Predicted band size: 32 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXXC5 antibody (ab106533)
Immunohistochemistry of CXXC5 in human brain tissue with ab106533 at 2.5 µg/ml.
Immunocytochemistry/ Immunofluorescence - Anti-CXXC5 antibody (ab106533)
Immunofluorescence of CXXC5 in Human Brain cells using ab106533 at 20 ug/ml.
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