Anti-CYB5B antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The CYB5B protein also known as Cytochrome b5 type B is a microsomal enzyme with an approximate mass of 13.4 kDa. It resides mainly in the endoplasmic reticulum membrane playing a role in electron transfer activities. This protein is expressed in various tissues with notable presence in the liver and adrenal glands. Unlike its mitochondrial counterparts CYB5B is involved in several mixed-function oxidase systems contributing to the catalysis of reactions through electron transfer.

Biological function summary

Cytochrome b5 type B interacts with a wide range of oxidoreductase enzymes which assists in lipid biosynthesis. It acts as a component of the electron transport chain within the endoplasmic reticulum supporting the desaturation and elongation of fatty acids. Though not part of a larger complex its role in electron donation is critical for maintaining cellular lipid homeostasis and synthesizing essential fatty acids.

Pathways

CYB5B plays a role in both the fatty acid metabolic process and the sterol biosynthetic pathway. It provides electrons to desaturase enzymes like stearoyl-CoA desaturase facilitating the transformation of saturated fatty acids into unsaturated fatty acids. This electron relay is also integral to the modulation of cholesterol levels within cells and relates to proteins such as NADH-cytochrome b5 reductase that help transfer electrons from NADH to cytochrome b5.

Associated diseases and disorders

CYB5B alterations can impact conditions such as fatty liver disease and adrenal hyperplasia. Its functional collaboration with enzymes such as cytochrome P450 isoforms can influence steroid hormone biosynthesis especially in adrenal tissues. The dysregulation of CYB5B activity might affect lipid metabolic stability making it a point of interest in understanding lipid-associated metabolic and endocrine disorders.