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AB197908

Anti-CYP11B1 antibody

0

(1 Review)

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(3 Publications)

Rabbit Polyclonal CYP11B1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Fusion protein corresponding to CYP11B1, fused to CYP11B1.

View Alternative Names

S11BH, CYP11B1, CYPXIB1, Cytochrome P-450c11, Cytochrome P450C11

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP11B1 antibody (AB197908)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP11B1 antibody (AB197908)

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling CYP11B1 with ab197908 at 1/25 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP11B1 antibody (AB197908)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP11B1 antibody (AB197908)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling CYP11B1 with ab197908 at 1/25 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Fusion protein corresponding to CYP11B1, fused to CYP11B1. The exact immunogen used to generate this antibody is proprietary information.

P15538

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Alternative Products

Primary Antibodies

AB171888

Anti-CYP11B1 antibody

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Primary Antibodies

AB229884

Anti-CYP11B1 antibody

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Complementary Products

Primary Antibodies

AB167413

Anti-C11B2/CYP11B2 antibody [EPR10495]

RabMAb|Recombinant

Western blot - Anti-C11B2/CYP11B2 antibody [EPR10495] (AB167413)

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Primary Antibodies

AB134910

Anti-Cytochrome P450 17A1/CYP17A1 antibody [EPR6294(2)]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 17A1/CYP17A1 antibody [EPR6294(2)] (AB134910)

  • 1
  • 1
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Primary Antibodies

AB272494

Anti-CYP11A1 antibody [EPR24868-86]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Flow Cytometry (Intracellular) - Anti-CYP11A1 antibody [EPR24868-86] (AB272494)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CYP11B1 also known as cytochrome P450 11B1 or steroid 11β-hydroxylase is a mitochondrial enzyme responsible for the conversion of 11-deoxycorticosterone to corticosterone and 11-deoxycortisol to cortisol. This enzyme plays a significant role in steroidogenesis and its molecular mass measures approximately 57 kDa. It is expressed mainly in the adrenal cortex particularly within the zona fasciculata and zona glomerulosa of the adrenal glands.
Biological function summary

CYP11B1 functions as an essential enzyme in the production of glucocorticoids such as cortisol. These glucocorticoids are critical in regulating metabolism immune response and stress. CYP11B1 is part of the larger cytochrome P450 family a group involved in numerous chemical reactions within the body especially those pertaining to drug metabolism and hormone synthesis.

Pathways

Steroidogenesis includes the actions of CYP11B1 functioning in the biosynthetic pathway of adrenal steroids. This pathway generates important hormones like cortisol. Within this pathway CYP11B1 works closely with other proteins such as CYP17A1 and CYP21A2 which also contribute to steroid hormone biosynthesis. The balance of these enzymatic activities determines the hormonal output of the adrenal cortex.

Dysregulation of CYP11B1 activity has been associated with congenital adrenal hyperplasia (CAH) and Cushing's syndrome. CAH involves a deficiency in cortisol production often resulting from mutations in the CYP11B1 gene. Meanwhile Cushing's syndrome may arise due to excessive cortisol production. CYP21A2 another enzyme in steroidogenesis can also have mutations that contribute to adrenal disorders showing a genetic link between the two.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed : 12530636, PubMed : 1518866, PubMed : 1775135, PubMed : 18215163, PubMed : 23322723). Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19 (By similarity). Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone (PubMed : 12530636, PubMed : 1518866, PubMed : 1775135, PubMed : 18215163, PubMed : 23322723). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed : 18215163). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone (PubMed : 23322723). Could also be involved in the androgen metabolic pathway (Probable).
See full target information CYP11B1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

European journal of endocrinology 192:191-201 PubMed39960854

2025

Discordance between adrenal vein sampling and imaging: the role of unilateral cortisol excess.

Applications

Unspecified application

Species

Unspecified reactive species

Megan Grundy,Alexander A Leung,Martin Hyrcza,Janice L Pasieka,Denise Chan,Stefan J Przybojewski,Chi-Bun Benny So,Dennis Orton,Adrian Harvey,Gregory A Kline

Frontiers in cell and developmental biology 12:1469955 PubMed39839668

2025

Comparative evaluation of ACetic - MEthanol high salt dissociation approach for single-cell transcriptomics of frozen human tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Marina Utkina,Anastasia Shcherbakova,Ruslan Deviatiiarov,Alina Ryabova,Marina Loguinova,Valentin Trofimov,Anna Kuznetsova,Mikhail Petropavlovskiy,Rustam Salimkhanov,Denis Maksimov,Eugene Albert,Alexandra Golubeva,Walaa Asaad,Lilia Urusova,Ekaterina Bondarenko,Anastasia Lapshina,Alexandra Shutova,Dmitry Beltsevich,Oleg Gusev,Larisa Dzeranova,Galina Melnichenko,Ildar Minniakhmetov,Ivan Dedov,Natalya Mokrysheva,Sergey Popov

Scientific reports 10:7795 PubMed32385361

2020

Eyes shut homolog (EYS) interacts with matriglycan of O-mannosyl glycans whose deficiency results in EYS mislocalization and degeneration of photoreceptors.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Liu,Miao Yu,Xuanze Shang,My Hong Hoai Nguyen,Shanmuganathan Balakrishnan,Rachel Sager,Huaiyu Hu
View all publications
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