Rabbit Polyclonal CYP26A1 antibody. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CYP26A1 aa 200 to C-terminus.
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- Journal of cellular and molecular medicine 26:2438-24502022Cytochrome P450 26A1 regulates the clusters and killing activity of NK cells during the peri-implantation period.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDan-Dan Li,Wen-Heng Ji,Dan-Ping Wei,Ai-Qin Gu,Zhi-Hui Song,Wen-Ning Fang,Chao-Yang Meng,Ying Yang,Jing-Pian PengPubMed 35297206
- Frontiers in immunology 12:7630672021Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWen-Heng Ji,Dan-Dan Li,Dan-Ping Wei,Ai-Qin Gu,Ying Yang,Jing-Pian PengPubMed 34712245
- Journal of cellular and molecular medicine 25:1771-17822021A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDan-Ping Wei,Dan-Dan Li,Ai-Qin Gu,Wen-Heng Ji,Ying Yang,Jing-Pian PengPubMed 33438367
- Journal of cellular and molecular medicine 23:5403-54142019Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAi-Qin Gu et. al.PubMed 31148354
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human CYP26A1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O43174
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Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Tested | Expected |
| Rat | Predicted | Predicted |
| Cow | Predicted | Predicted |
| Monkey | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100 - 1/1000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Human | Dilution info 1/100 - 1/1000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Cow, Monkey | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/3000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Cow, Monkey | Dilution info - | Notes - |
Target data
Function
A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:22020119, PubMed:9228017, PubMed:9716180). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed:22020119, PubMed:9228017, PubMed:9716180). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity) (PubMed:9228017). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021).
Alternative names
CYP26, P450RAI1, CYP26A1, Cytochrome P450 26A1, Cytochrome P450 retinoic acid-inactivating 1, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome, Cytochrome P450RAI, hP450RAI
Recommended products
Rabbit Polyclonal CYP26A1 antibody. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CYP26A1 aa 200 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human CYP26A1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O43174
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CYP26A1 also known as Cytochrome P450 26A1 is a member of the cytochrome P450 superfamily responsible for the metabolism of endogenous and exogenous compounds. This enzyme weighs approximately 55 kDa. It plays an important role in the oxidative metabolism of retinoic acid a form of vitamin A. Predominantly it is expressed in the liver but expression is also seen in other tissues like brain and placenta. Monoclonal antibodies targeting CYP26A1 can facilitate research to better understand these expressions.
- Biological function summary
CYP26A1 controls the levels of retinoic acid within cells by catalyzing its 4-hydroxylation ensuring precise regulation of cellular differentiation and proliferation. It is a part of the broader retinoid metabolism system which involves several other P450 enzymes that ensure the metabolic balance of retinoic acid. CYP26A1 works with these enzymes to tightly regulate this critical signaling molecule's presence impacting development processes.
- Pathways
CYP26A1 significantly contributes to the retinol metabolism pathway and the broader retinoid signaling pathway. Its action helps manage the intricate balance of retinoic acid connecting it functionally to other cytochrome P450 enzymes like CYP26B1. These pathways play essential roles in modulating gene expression patterns during embryonic development and tissue differentiation.
- Associated diseases and disorders
CYP26A1's dysregulation relates to disorders such as congenital diaphragmatic hernia and certain cancers. Altered enzymatic activity affects retinoic acid levels leading to disrupted tissue differentiation and development. In some cancers proteins like retinoic acid receptor alpha (RARA) interact with dysregulated retinoic acid levels due to CYP26A1 anomalies influencing cancer progression and potential therapeutic targets.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
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3 product images
Western blot - Anti-CYP26A1 antibody (ab151968)
7.5% SDS PAGE
All lanes: Western blot - Anti-CYP26A1 antibody (ab151968) at 1/1000 dilution
All lanes: 293T whole cell lysate at 30 µg
Predicted band size: 56 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP26A1 antibody (ab151968)
Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue labeling CYP26A1 with ab151968 at 1/500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP26A1 antibody (ab151968)
Immunohistochemical analysis of paraffin-embedded Mouse muscle tissue labeling CYP26A1 with ab151968 at 1/500 dilution.
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