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AB151968

Anti-CYP26A1 antibody

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(4 Publications)

Rabbit Polyclonal CYP26A1 antibody. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CYP26A1 aa 200 to C-terminus.

View Alternative Names

CYP26, P450RAI1, CYP26A1, Cytochrome P450 26A1, Cytochrome P450 retinoic acid-inactivating 1, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome, Cytochrome P450RAI, hP450RAI

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP26A1 antibody (AB151968)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP26A1 antibody (AB151968)

Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue labeling CYP26A1 with ab151968 at 1/500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP26A1 antibody (AB151968)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP26A1 antibody (AB151968)

Immunohistochemical analysis of paraffin-embedded Mouse muscle tissue labeling CYP26A1 with ab151968 at 1/500 dilution.

Western blot - Anti-CYP26A1 antibody (AB151968)
  • WB

Unknown

Western blot - Anti-CYP26A1 antibody (AB151968)

7.5% SDS PAGE

All lanes:

Western blot - Anti-CYP26A1 antibody (ab151968) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 56 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human CYP26A1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43174

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CYP26A1 also known as Cytochrome P450 26A1 is a member of the cytochrome P450 superfamily responsible for the metabolism of endogenous and exogenous compounds. This enzyme weighs approximately 55 kDa. It plays an important role in the oxidative metabolism of retinoic acid a form of vitamin A. Predominantly it is expressed in the liver but expression is also seen in other tissues like brain and placenta. Monoclonal antibodies targeting CYP26A1 can facilitate research to better understand these expressions.
Biological function summary

CYP26A1 controls the levels of retinoic acid within cells by catalyzing its 4-hydroxylation ensuring precise regulation of cellular differentiation and proliferation. It is a part of the broader retinoid metabolism system which involves several other P450 enzymes that ensure the metabolic balance of retinoic acid. CYP26A1 works with these enzymes to tightly regulate this critical signaling molecule's presence impacting development processes.

Pathways

CYP26A1 significantly contributes to the retinol metabolism pathway and the broader retinoid signaling pathway. Its action helps manage the intricate balance of retinoic acid connecting it functionally to other cytochrome P450 enzymes like CYP26B1. These pathways play essential roles in modulating gene expression patterns during embryonic development and tissue differentiation.

CYP26A1's dysregulation relates to disorders such as congenital diaphragmatic hernia and certain cancers. Altered enzymatic activity affects retinoic acid levels leading to disrupted tissue differentiation and development. In some cancers proteins like retinoic acid receptor alpha (RARA) interact with dysregulated retinoic acid levels due to CYP26A1 anomalies influencing cancer progression and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed : 22020119, PubMed : 9228017, PubMed : 9716180). RAs exist as at least four different isomers : all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed : 22020119, PubMed : 9228017, PubMed : 9716180). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity) (PubMed : 9228017). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed : 26937021).
See full target information CYP26A1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 26:2438-2450 PubMed35297206

2022

Cytochrome P450 26A1 regulates the clusters and killing activity of NK cells during the peri-implantation period.

Applications

Unspecified application

Species

Unspecified reactive species

Dan-Dan Li,Wen-Heng Ji,Dan-Ping Wei,Ai-Qin Gu,Zhi-Hui Song,Wen-Ning Fang,Chao-Yang Meng,Ying Yang,Jing-Pian Peng

Frontiers in immunology 12:763067 PubMed34712245

2021

Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.

Applications

Unspecified application

Species

Unspecified reactive species

Wen-Heng Ji,Dan-Dan Li,Dan-Ping Wei,Ai-Qin Gu,Ying Yang,Jing-Pian Peng

Journal of cellular and molecular medicine 25:1771-1782 PubMed33438367

2021

A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.

Applications

Unspecified application

Species

Unspecified reactive species

Dan-Ping Wei,Dan-Dan Li,Ai-Qin Gu,Wen-Heng Ji,Ying Yang,Jing-Pian Peng

Journal of cellular and molecular medicine 23:5403-5414 PubMed31148354

2019

Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Ai-Qin Gu,Dan-Dan Li,Dan-Ping Wei,Yan-Qin Liu,Wen-Heng Ji,Ying Yang,Han-Yan Lin,Jing-Pian Peng
View all publications
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