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AB223785

Anti-CYP2A13 antibody

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(1 Publication)

Rabbit Polyclonal CYP2A13 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Cytochrome P450 2A13 aa 350-450.

View Alternative Names

Cytochrome P450 2A13, CYPIIA13, CYP2A13

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2A13 antibody (AB223785)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2A13 antibody (AB223785)

Paraffin-embedded human liver tissue stained for CYP2A13 using ab223785 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Cytochrome P450 2A13 aa 350-450. The exact immunogen used to generate this antibody is proprietary information.

Q16696

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CYP2A13 also known as Cytochrome P450 2A13 is an enzyme encoded by the CYP2A13 gene located on chromosome 19. The enzyme has a molecular mass of approximately 56 kDa. It functions in the oxidation of various endogenous and exogenous compounds including the metabolism of toxins such as nicotine. CYP2A13 is prominently expressed in tissue such as the respiratory tract especially in the nasal mucosa and lung tissues as well as in the liver to a lesser extent.
Biological function summary

CYP2A13 influences the metabolic processing of xenobiotics. It belongs to the cytochrome P450 superfamily which is a group of enzymes essential for drug metabolism and the synthesis of cholesterol steroids and other lipids. While it does not form a complex itself it actively contributes to bioactivation processes that convert chemical compounds into reactive intermediates. This role is important for how the body handles and processes potential toxins or therapeutic drugs.

Pathways

The enzyme plays a notable role in the metabolism of xenobiotics by cytochrome P450. This pathway is key in converting lipophilic compounds into hydrophilic products for easier excretion. CYP2A13 is also involved in the metabolism of nicotine making it a part of the broader nicotine degradation pathway. It shares functional similarities with other cytochrome P450 family members like CYP2A6 which also participates in nicotine metabolism.

CYP2A13 has been linked to respiratory-related conditions such as lung cancer due to its involvement in the metabolic activation of tobacco-specific nitrosamines. The enzyme converts these compounds into DNA-damaging agents increasing cancer risk. Furthermore its expression in the lung tissue suggests a potential impact on other respiratory diseases. CYP2A13's metabolic activities overlap with those of CYP1A2 another enzyme related to carcinogen activation highlighting their combined relevance in tobacco-related cancers.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
See full target information Cytochrome P450 2A13

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal for immunotherapy of cancer 13: PubMed40954077

2025

LncRNA-CTD suppresses metastasis and immune evasion by modulating snail1 and MHC-I expression in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Xu,Huisi Qiu,Yuezhang Sun,Hong Jin,Siyu Yan,Fangmei Zhang,Ying Song,Guopei Zheng,Dongjiang Liao,Xiaoli Wei,Liyun Luo
View all publications

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