Skip to main content

Mouse Monoclonal CYPIVF11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human CYP4F11.

Be the first to review this product! Submit a review

Images

Western blot - Anti-CYPIVF11 antibody [F21 P6 F5] (AB55841), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYPIVF11 antibody [F21 P6 F5] (AB55841), expandable thumbnail

Key facts

Isotype

IgG1

Host species

Mouse

Storage buffer

Preservative: 0.08% Sodium azide
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • Synthetic Peptide within Human CYP4F11. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HBI6

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested

Tested
Tested

Species

Human

Dilution info

1.00000-2.00000 µg/mL

Notes

-

Tested
Tested

Species

Human

Dilution info

1.00000-5.00000 µg/mL

Notes

-

Target data

Function

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545).

Alternative names

Cytochrome P450 4F11, CYPIVF11, 3-hydroxy fatty acids omega-hydroxylase CYP4F11, Docosahexaenoic acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase, Phylloquinone omega-hydroxylase CYP4F11, CYP4F11

Recommended products

Mouse Monoclonal CYPIVF11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human CYP4F11.

Alternative names

Cytochrome P450 4F11, CYPIVF11, 3-hydroxy fatty acids omega-hydroxylase CYP4F11, Docosahexaenoic acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase, Phylloquinone omega-hydroxylase CYP4F11, CYP4F11

Key facts

Isotype

IgG1

Form

Liquid

Clonality

Monoclonal

Immunogen
  • Synthetic Peptide within Human CYP4F11. The exact immunogen used to generate this antibody is proprietary information. Database link Q9HBI6
Clone number

F21 P6 F5

Purification technique

Affinity purification Protein G

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CYPIVF11 also known as Cytochrome P450 Family 4 Subfamily F Member 11 functions as a monooxygenase enzyme involved in the oxidation of organic substances. It plays a role in drug metabolism and the synthesis of cholesterol steroids and other lipids. The enzyme has a mass of approximately 54 kDa. CYPIVF11 is predominantly expressed in hepatic tissues where it contributes to metabolic processes.

Biological function summary

CYPIVF11 mediates the oxidative breakdown of fatty acids. It participates in epoxygenation reactions and helps to convert long chain fatty acids into metabolites that are used by the body. CYPIVF11 might interact with other cytochrome P450 enzymes forming a complex network that enhances broad substrate specificity and metabolic capacity.

Pathways

CYPIVF11 engages in the arachidonic acid metabolism and the fatty acid degradation pathways. It associates with proteins such as CYP4A11 and CYP4F2 within these pathways contributing to the modulation of inflammatory responses by converting arachidonic acid into bioactive lipid mediators. This function connects it closely with lipid homeostasis and energy metabolism.

Associated diseases and disorders

Aberrant expression or function of CYPIVF11 links to cardiovascular diseases and liver disorders. Its role in lipid metabolism relates it to the inflammatory pathways that are often upregulated in atherosclerosis. Through interactions with proteins like CYP4F12 it has implications in the development of liver pathologies associated with impaired detoxification processes.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Western blot - Anti-CYPIVF11 antibody [F21 P6 F5] (ab55841), expandable thumbnail

    Western blot - Anti-CYPIVF11 antibody [F21 P6 F5] (ab55841)

    All lanes: Western blot - Anti-CYPIVF11 antibody [F21 P6 F5] (ab55841) at 1 µg/mL

    Lane 2: normal kidney cell lysate at 20 µg

    Lane 3: kidney cancer cell lysate at 20 µg

    Predicted band size: 60 kDa

    Observed band size: 60 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYPIVF11 antibody [F21 P6 F5] (ab55841), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYPIVF11 antibody [F21 P6 F5] (ab55841)

    ab55841 at 1 μg/ml staining human liposarcoma cells; formalin fixed, paraffin embedded.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com