AB55841

Anti-CYPIVF11 antibody [F21 P6 F5]

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Mouse Monoclonal CYPIVF11 antibody F21 P6 F5. Suitable for WB, IHC-P and reacts with Human samples.

View Alternative Names

Cytochrome P450 4F11, CYPIVF11, 3-hydroxy fatty acids omega-hydroxylase CYP4F11, Docosahexaenoic acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase, Phylloquinone omega-hydroxylase CYP4F11, CYP4F11

2 Images

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Western blot - Anti-CYPIVF11 antibody [F21 P6 F5] (AB55841)

All lanes:

Western blot - Anti-CYPIVF11 antibody [F21 P6 F5] (ab55841) at 1 µg/mL

Lane 2:

normal kidney cell lysate at 20 µg

Lane 3:

kidney cancer cell lysate at 20 µg

Predicted band size: 60 kDa

Observed band size: 60 kDa

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYPIVF11 antibody [F21 P6 F5] (AB55841)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYPIVF11 antibody [F21 P6 F5] (AB55841)

ab55841 at 1 μg/ml staining human liposarcoma cells; formalin fixed, paraffin embedded.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

F21 P6 F5

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CYP4F11. The exact immunogen used to generate this antibody is proprietary information.

Q9HBI6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1.00000-2.00000 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1.00000-5.00000 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

Preservative: 0.08% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CYPIVF11 also known as Cytochrome P450 Family 4 Subfamily F Member 11 functions as a monooxygenase enzyme involved in the oxidation of organic substances. It plays a role in drug metabolism and the synthesis of cholesterol steroids and other lipids. The enzyme has a mass of approximately 54 kDa. CYPIVF11 is predominantly expressed in hepatic tissues where it contributes to metabolic processes.

Biological function summary

CYPIVF11 mediates the oxidative breakdown of fatty acids. It participates in epoxygenation reactions and helps to convert long chain fatty acids into metabolites that are used by the body. CYPIVF11 might interact with other cytochrome P450 enzymes forming a complex network that enhances broad substrate specificity and metabolic capacity.

Pathways

CYPIVF11 engages in the arachidonic acid metabolism and the fatty acid degradation pathways. It associates with proteins such as CYP4A11 and CYP4F2 within these pathways contributing to the modulation of inflammatory responses by converting arachidonic acid into bioactive lipid mediators. This function connects it closely with lipid homeostasis and energy metabolism.

Aberrant expression or function of CYPIVF11 links to cardiovascular diseases and liver disorders. Its role in lipid metabolism relates it to the inflammatory pathways that are often upregulated in atherosclerosis. Through interactions with proteins like CYP4F12 it has implications in the development of liver pathologies associated with impaired detoxification processes.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed : 15364545, PubMed : 18065749, PubMed : 24138531, PubMed : 37373382). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed : 15364545, PubMed : 18065749, PubMed : 24138531, PubMed : 37373382). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed : 18065749, PubMed : 19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed : 24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed : 15364545, PubMed : 19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed : 15364545). Catalyzes the oxidation of dialkylresorcinol 2 (PubMed : 36565673).

See full target information CYP4F11

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Product promise

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