JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB124281

Anti-Cystatin SN/CST1 antibody

Be the first to review this product! Submit a review

|

(5 Publications)

Rabbit Polyclonal Cystatin SN/CST1 antibody. Suitable for ELISA, ICC/IF, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CST1.

View Alternative Names

Cystatin-SN, Cystain-SA-I, Cystatin-1, Salivary cystatin-SA-1, CST1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cystatin SN/CST1 antibody (AB124281)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cystatin SN/CST1 antibody (AB124281)

ab124281, at 5μg/ml, staining Cystatin SN/CST1 in formalin-fixed, paraffin-embedded Human prostate tissue.

Immunocytochemistry/ Immunofluorescence - Anti-Cystatin SN/CST1 antibody (AB124281)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Cystatin SN/CST1 antibody (AB124281)

Immunofluorescence analysis of MCF7 cells, using ab124281at 1/100 dilution. The picture on the right is treated with the synthesized peptide.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, ELISA

applications

Immunogen

Synthetic Peptide within Human CST1. The exact immunogen used to generate this antibody is proprietary information.

P01037

style
left-column

Alternative Products

Primary Antibodies

AB68329

Anti-Cystatin SN/CST1 antibody

Western blot - Anti-Cystatin SN/CST1 antibody (AB68329)

  • 0
  • 0

Complementary Products

Assay Kits

AB314725

Human Cystatin SN/CST1 ELISA Kit

Sandwich ELISA - Human Cystatin SN/CST1 ELISA Kit (AB314725)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB32503

Anti-Bax antibody [E63]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bax antibody [E63] (AB32503)

  • 4
  • 12
Primary Antibodies

AB259498

Anti-IL-4R antibody [EPR21947-278] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-IL-4R antibody [EPR21947-278] - BSA and Azide free (Detector) (AB259498)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cystatin SN also known as CST1 is a cysteine protease inhibitor that belongs to the family of cystatins. This protein has a mass of approximately 16 kDa and is expressed primarily in human saliva as well as other tissues like the nasal mucosa and skin. Its main role involves binding to and inhibiting cathepsins and other cysteine protease enzymes preventing the breakdown of cellular and extracellular proteins. Such inhibition protects tissues from damage and helps maintain normal protein turnover.
Biological function summary

CST1 inhibits proteolytic enzymes that are involved in degrading proteins within cells and tissues. This protein is not part of a larger complex but instead exerts its function through one-on-one interactions with target proteases. Through its inhibitory actions CST1 plays a protective role in various bodily fluids and epithelial surfaces contributing to the body's barrier and immune defense mechanisms against pathogens and tissue damage.

Pathways

CST1 is engaged in the regulation of protease activity which impacts the broader proteolytic pathways that are important to cellular homeostasis. This regulation is linked to the lysosomal cathepsin family and pathways such as the protein metabolism pathway. Related proteins within these pathways include cathepsin L and cathepsin B which are also cysteine proteases that rely on precise regulation by cystatin family proteins like CST1 to prevent excessive protein degradation.

CST1 has associations with conditions like chronic rhinosinusitis and certain cancers. Chronic rhinosinusitis involves excessive inflammation and tissue damage a process where CST1's inhibition of proteases like cathepsin B is important. In cancer abnormal CST1 expression levels have been noted in gastric and colorectal cancers suggesting a connection with tumor growth and metastasis. In these contexts altered expression or function of CST1 may interact with other proteins such as cathepsin L influencing disease progression.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
See full target information CST1
style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 17: PubMed40005052

2025

Alteration of Gastrointestinal Function and the Ameliorative Effects of Polysaccharides in Tail Suspension Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Zang,Pu Chen,Junli Chen,Jingchao Sun,Haiyun Lan,Haisheng Dong,Wei Liu,Nan Xu,Weiran Wang,Lingwei Hou,Bowen Sun,Lujia Zhang,Jiaqiang Huang,Pengjie Wang,Fazheng Ren,Siyuan Liu

Medical science monitor : international medical journal of experimental and clinical research 30:e943551 PubMed38959178

2024

Cystatin SN (CST1) Is a Poor Independent Prognostic Biomarker for Gastrointestinal Diffuse Large B-Cell Lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Wang,Ming Yang,Sheng Chen,Hongbo Zhu,Zhirong Zhang

Technology in cancer research & treatment 21:15330338221117003 PubMed35899307

2022

Weighted Correlation Network Analysis of Cancer Stem Cell-Related Prognostic Biomarkers in Esophageal Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Mengnan Zhao,Xing Jin,Zhencong Chen,Huan Zhang,Cheng Zhan,Hao Wang,Qun Wang

Journal of oncology 2022:6406943 PubMed35498540

2022

Role of the Long Intergenic Non-Protein-Coding RNA 1278/miR-185-5p/Cystatin SN Axis in Laryngeal Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Shen,Haibin Ding,Yanyan Ye,Baozhen Luo

Molecular medicine reports 24: PubMed34278468

2021

Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin‑SN.

Applications

Unspecified application

Species

Unspecified reactive species

Wenying Gao,Zhenglong Jin,Yanxia Zheng,Youjia Xu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com