AB232699

Anti-Cysteine Dioxygenase CDO1 antibody

Name: Anti-Cysteine Dioxygenase CDO1 antibody (ab232699) | Abcam
Brand: Abcam Limited
SKU: AB232699

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(5 Publications)

Rabbit Polyclonal Cysteine Dioxygenase CDO1 antibody. Suitable for WB and reacts with Rat, Pig samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Cysteine dioxygenase type 1.

View Alternative Names

Cysteine dioxygenase type 1, Cysteine dioxygenase type I, CDO, CDO-I, CDO1

2 Images

Supplier Data

Western blot - Anti-Cysteine Dioxygenase CDO1 antibody (AB232699)

All lanes:

Western blot - Anti-Cysteine Dioxygenase CDO1 antibody (ab232699) at 3 µg/mL

All lanes:

Rat liver lysate

Predicted band size: 23 kDa

false

Supplier Data

Western blot - Anti-Cysteine Dioxygenase CDO1 antibody (AB232699)

All lanes:

Western blot - Anti-Cysteine Dioxygenase CDO1 antibody (ab232699) at 2 µg/mL

All lanes:

Pig liver lysate

Predicted band size: 23 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Pig

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Cysteine dioxygenase type 1.

Q16878

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab232699 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cysteine Dioxygenase CDO1 also known as CDO is a non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid. This enzyme plays an important mechanical role in maintaining proper levels of cysteine within cells. With a molecular weight of approximately 23 kDa CDO1 is expressed mainly in the liver although it can be found in various tissues where it helps regulate cysteine concentration and detoxification processes.

Biological function summary

Cysteine dioxygenase participates in sulfur metabolism and it functions as a monomer. The enzyme ensures sulfur balance by transforming excess cysteine which can be toxic if accumulated. This metabolic process impacts taurine and sulfate production vitally affecting cellular and systemic functions. CDO1 modulates cellular responses to cysteine levels by contributing to these metabolic pathways providing necessary components for other cellular activities and detoxifying mechanisms.

Pathways

The oxidation of cysteine by CDO1 feeds into the taurine and hypotaurine metabolism as well as the hydrogen sulfide biosynthesis pathways. These pathways are integral to maintaining cellular redox balance and ion regulation. The enzyme’s activity connects it to proteins like cysteine aminotransferase and sulfite oxidase which further metabolize products from its catalytic activity integrating CDO1 into a broader metabolic network.

Cysteine dioxygenase has associations with neurodegenerative diseases and cancers. Imbalances in CDO1 activity can lead to altered cysteine homeostasis contributing to conditions such as Alzheimer's disease where oxidative stress often plays a role. Additionally dysregulation of CDO1 may influence cancer progression as altered cysteine metabolism is linked to tumor growth and survival. Proteins such as glutamate cysteine ligase may connect to CDO1 through shared pathways affecting oxidative stress and sulfur amino acid metabolism providing insights into disease mechanisms and potential therapeutic targets.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

See full target information Cysteine dioxygenase type 1

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:194 PubMed40269955

2025

CDO1 phosphorylation is required for IL-6-induced tumor cell proliferation through governing cysteine availability.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Li,Zhe Zhao,Hongping Ye,Dan Li,Xiaoke Huang,Jong-Ho Lee,Rui Liu

The Journal of biological chemistry 300:107680 PubMed39159808

2024

LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by promoting DNMT1-mediated CDO1 promoter hypermethylation.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiyu Wang,Xiuzhang Yu,Hui Ye,Mengyin Ao,Mingrong Xi,Minmin Hou

Nature communications 14:3392 PubMed37296100

2023

A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase.

Applications

Unspecified application

Species

Unspecified reactive species

Vinitha N Ragavan,Pramod C Nair,Natalia Jarzebska,Ramcharan Singh Angom,Luana Ruta,Elisa Bianconi,Silvia Grottelli,Natalia D Tararova,Daniel Ryazanskiy,Steven R Lentz,Sara Tommasi,Jens Martens-Lobenhoffer,Toshiko Suzuki-Yamamoto,Masumi Kimoto,Elena Rubets,Sarah Chau,Yingjie Chen,Xinli Hu,Nadine Bernhardt,Peter M Spieth,Norbert Weiss,Stefan R Bornstein,Debabrata Mukhopadhyay,Stefanie M Bode-Böger,Renke Maas,Ying Wang,Antonio Macchiarulo,Arduino A Mangoni,Barbara Cellini,Roman N Rodionov

Experimental biology and medicine (Maywood, N.J.) 246:1541-1553 PubMed33926261

2021

Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Siyue Lou,Huanwu Hong,Liwaliding Maihesuti,Hang Gao,Zhihui Zhu,Lili Xu,Shasha Tian,Guoyin Kai,Guozheng Huang,Huajun Zhao

Reproductive sciences (Thousand Oaks, Calif.) 28:79-90 PubMed32820455

2020

Estrogen Regulates Local Cysteine Metabolism in Mouse Myometrium.

Applications

Unspecified application

Species

Unspecified reactive species

Damian D Guerra,Rachael Bok,Kelsey Breen,Vibhuti Vyas,Hua Jiang,Kenneth N MacLean,K Joseph Hurt

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Cysteine Dioxygenase CDO1 antibody

Western blot - Anti-Cysteine Dioxygenase CDO1 antibody (AB232699)

Western blot - Anti-Cysteine Dioxygenase CDO1 antibody (AB232699)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise