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AB234693

Anti-Cysteine Dioxygenase CDO1 antibody

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(1 Publication)

Rabbit Polyclonal Cysteine Dioxygenase CDO1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Cysteine dioxygenase type 1.

View Alternative Names

Cysteine dioxygenase type 1, Cysteine dioxygenase type I, CDO, CDO-I, CDO1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cysteine Dioxygenase CDO1 antibody (AB234693)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cysteine Dioxygenase CDO1 antibody (AB234693)

Paraffin-embedded human pancreatic cancer tissue stained for Cysteine Dioxygenase CDO1 using ab234693 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cysteine Dioxygenase CDO1 antibody (AB234693)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cysteine Dioxygenase CDO1 antibody (AB234693)

Paraffin-embedded human liver cancer tissue stained for Cysteine Dioxygenase CDO1 using ab234693 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Cysteine dioxygenase type 1.

Q16878

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cysteine Dioxygenase CDO1 also known as CDO is a non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid. This enzyme plays an important mechanical role in maintaining proper levels of cysteine within cells. With a molecular weight of approximately 23 kDa CDO1 is expressed mainly in the liver although it can be found in various tissues where it helps regulate cysteine concentration and detoxification processes.
Biological function summary

Cysteine dioxygenase participates in sulfur metabolism and it functions as a monomer. The enzyme ensures sulfur balance by transforming excess cysteine which can be toxic if accumulated. This metabolic process impacts taurine and sulfate production vitally affecting cellular and systemic functions. CDO1 modulates cellular responses to cysteine levels by contributing to these metabolic pathways providing necessary components for other cellular activities and detoxifying mechanisms.

Pathways

The oxidation of cysteine by CDO1 feeds into the taurine and hypotaurine metabolism as well as the hydrogen sulfide biosynthesis pathways. These pathways are integral to maintaining cellular redox balance and ion regulation. The enzyme’s activity connects it to proteins like cysteine aminotransferase and sulfite oxidase which further metabolize products from its catalytic activity integrating CDO1 into a broader metabolic network.

Cysteine dioxygenase has associations with neurodegenerative diseases and cancers. Imbalances in CDO1 activity can lead to altered cysteine homeostasis contributing to conditions such as Alzheimer's disease where oxidative stress often plays a role. Additionally dysregulation of CDO1 may influence cancer progression as altered cysteine metabolism is linked to tumor growth and survival. Proteins such as glutamate cysteine ligase may connect to CDO1 through shared pathways affecting oxidative stress and sulfur amino acid metabolism providing insights into disease mechanisms and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
See full target information Cysteine dioxygenase type 1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Analytical cellular pathology (Amsterdam) 2020:5632342 PubMed33457194

2020

p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1.

Applications

Unspecified application

Species

Unspecified reactive species

Xuesong Han,Xudong Xiang,Hongying Yang,Hongping Zhang,Shuang Liang,Jie Wei,Jing Yu
View all publications
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Product promise

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