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AB129767

Anti-CYTL1 antibody

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(4 Publications)

Rabbit Polyclonal CYTL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CYTL1.

View Alternative Names

C4orf4, UNQ1942/PRO4425, CYTL1, Cytokine-like protein 1, Protein C17

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYTL1 antibody (AB129767)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYTL1 antibody (AB129767)

ab129767, at 1/50 dilution, staining CYTL1 in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Western blot - Anti-CYTL1 antibody (AB129767)
  • WB

Unknown

Western blot - Anti-CYTL1 antibody (AB129767)

All lanes:

Western blot - Anti-CYTL1 antibody (ab129767) at 1/500 dilution

Lane 1:

LOVO cell extract

Lane 2:

LOVO cell extract with synthesized peptide

Predicted band size: 16 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CYTL1. The exact immunogen used to generate this antibody is proprietary information.

Q9NRR1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab129767 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage buffer
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CYTL1 also known as cytokine-like protein 1 or C17orf99 is a protein that plays a role in various cellular processes. It has an approximate molecular mass of 19 kDa. Scientists have observed its expression in a wide range of tissues but it is particularly prominent in cartilage tissue and the immune system suggesting its involvement in functions related to these areas. CYTL1 does not appear to have a highly specific pattern of distribution as it is also found in the respiratory and cardiovascular systems making its mechanical functions intriguing for further research.
Biological function summary

CYTL1 acts as a regulator in processes like cell adhesion migration and immune responses. While it isn't part of a larger complex it interacts closely with other cellular components to modulate these activities. Within immune responses CYTL1 contributes by modulating cytokine signaling potentially influencing the behavior of immune cells in response to inflammatory signals. This regulation is essential in maintaining a balanced immune environment and preventing excessive inflammation.

Pathways

CYTL1's biological function connects to the NF-kB and JAK-STAT signaling pathways. In the NF-kB pathway CYTL1 indirectly influences the expression of genes involved in inflammation and apoptosis. While in the JAK-STAT pathway CYTL1 modulation aids in mediating the effects of cytokines and promotes immune cell proliferation and differentiation. Related proteins like IL-6 and TNF-alpha often interact within these pathways and CYTL1 acts as a modulating entity that helps fine-tune the cellular responses.

Researchers have linked CYTL1 to potential roles in osteoarthritis and rheumatoid arthritis. In these conditions its expression level might affect cartilage integrity and inflammatory response. CYTL1 may interact with other proteins like MMPs (matrix metalloproteinases) in arthritis facilitating changes in cartilage matrix components. Understanding the precise role of CYTL1 in these diseases could offer new insights into therapeutic targets for mitigating joint degradation and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CYTL1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Clinical and experimental pharmacology & physiology 51:e13913 PubMed39103233

2024

Down-regulation of CYTL1 attenuates bleomycin-induced pulmonary fibrosis in mice by inhibiting M2 macrophage polarization via the TGF-β/CCN2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Wang,Chenxi Liu,Yi Xie,Xiaomei Li

Redox biology 70:103034 PubMed38211443

2024

Breast cancer cells have an increased ferroptosis risk induced by system x blockade after deliberately downregulating CYTL1 to mediate malignancy.

Applications

Unspecified application

Species

Unspecified reactive species

Wenwen Xue,Ying Yu,Yongzhong Yao,Lin Zhou,Ying Huang,Yixuan Wang,Zhixiu Chen,Liwei Wang,Xinran Li,Xiaoning Wang,Ronghui Du,Yan Shen,Qiang Xu

Frontiers in genetics 14:1118889 PubMed37124627

2023

Unveiling DNA damage repair-based molecular subtypes, tumor microenvironment and pharmacogenomic landscape in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weiqi Kong,Zhiqiang Wang,Bingyi Wang

PloS one 11:e0147424 PubMed26800213

2016

Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation.

Applications

ELISA

Species

Unspecified reactive species

Zhichao Ai,Wei Jing,Li Fang
View all publications
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Product promise

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