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Rabbit Recombinant Monoclonal Cytochrome b-c1 complex subunit 9/UQCR10 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.

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Images

Western blot - Anti-Cytochrome b-c1 complex subunit 9/UQCR10 antibody [EPR8178] - BSA and Azide free (AB250382), expandable thumbnail
  • Immunoprecipitation - Anti-Cytochrome b-c1 complex subunit 9/UQCR10 antibody [EPR8178] - BSA and Azide free (AB250382), expandable thumbnail
  • Western blot - Anti-Cytochrome b-c1 complex subunit 9/UQCR10 antibody [EPR8178] - BSA and Azide free (AB250382), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2 - 7.4
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IPWB
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

-

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

-

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 products for Alternative Version

    Target data

    Function

    Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.

    Alternative names

    Cytochrome b-c1 complex subunit 9, Complex III subunit 9, Complex III subunit X, Cytochrome c1 non-heme 7 kDa protein, Ubiquinol-cytochrome c reductase complex 7.2 kDa protein, HSPC119, UCRC, UQCR10

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    Rabbit Recombinant Monoclonal Cytochrome b-c1 complex subunit 9/UQCR10 antibody. Carrier free. Suitable for IP, WB and reacts with Human samples.

    Alternative names

    Cytochrome b-c1 complex subunit 9, Complex III subunit 9, Complex III subunit X, Cytochrome c1 non-heme 7 kDa protein, Ubiquinol-cytochrome c reductase complex 7.2 kDa protein, HSPC119, UCRC, UQCR10

    Key facts

    Isotype

    IgG

    Form

    Liquid

    Clonality

    Monoclonal

    Immunogen
    • The exact immunogen used to generate this antibody is proprietary information.
    Carrier free

    Yes

    Clone number

    EPR8178

    Purification technique

    Affinity purification

    Concentration
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    Storage

    Shipped at conditions

    Blue Ice

    Appropriate long-term storage conditions

    +4°C

    Storage information

    Do Not Freeze

    Notes

    ab250382 is the carrier-free version of Anti-Cytochrome b-c1 complex subunit 9/UQCR10 antibody [EPR8178] ab181154.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free batch production

    For more information, read more on recombinant antibodies.

    Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

    This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

    Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

    Supplementary info

    Activity summary

    Cytochrome b-c1 complex subunit 9 also known as UQCR10 is a small protein with a mass of approximately 7.6 kDa. It functions as a component of the cytochrome b-c1 complex which is an essential part of the mitochondrial electron transport chain. One can find UQCR10 expressed primarily in the inner mitochondrial membrane critical for cellular respiration and energy production. The role of UQCR10 within the complex is to stabilize the interaction between other subunits therefore maintaining the integrity of the cytochrome b-c1 complex.

    Biological function summary

    UQCR10 participates in facilitating electron transfer within the cytochrome b-c1 complex also known as Complex III of the mitochondrial respiratory chain. This complex comprises multiple protein subunits including cytochrome b cytochrome c1 and others. UQCR10 aids in the translocation of protons across the mitochondrial membrane contributing to the proton gradient necessary for ATP synthesis. This electron transfer process is vital for the production of cellular energy.

    Pathways

    The function of UQCR10 is integral to the oxidative phosphorylation pathway. This pathway involves several key processes within mitochondria that result in the synthesis of ATP. UQCR10 alongside cytochrome c1 and other subunits assists in the electron transfer from ubiquinol to cytochrome c. By facilitating these electron transfer reactions UQCR10 plays an important role in aerobic respiration and cellular energy metabolism.

    Associated diseases and disorders

    UQCR10 has connections to mitochondrial disorders and neurodegenerative diseases. Mutations affecting the cytochrome b-c1 complex can lead to mitochondrial dysfunction impacting energy production and leading to conditions such as Leigh syndrome and other mitochondrial myopathies. The role of UQCR10 in stabilizing the cytochrome complex makes it relevant in understanding disease mechanisms alongside related proteins like cytochrome c1 that can influence disease outcomes.

    Product promise

    We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

    In the unlikely event of one of our products not working as expected, you are covered by our product promise.

    Full details and terms and conditions can be found here:
    Terms & Conditions.

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    Product protocols

    For this product, it's our understanding that no specific protocols are required. You can:

    Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

    For licensing inquiries, please contact partnerships@abcam.com