Anti-Cytochrome P450 2B1 + 2B2 antibody [b/e3 (9.14)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cytochrome P450 2B1 and 2B2 are enzymes that belong to the cytochrome P450 superfamily often referred to as CYP2B1 and CYP2B2 respectively. They are important in drug metabolism and chemical biotransformation. These enzymes have a role in oxidizing organic substances which helps in processing drugs in the liver. Each has a molecular mass of around 54 kDa and shows expression in tissues primarily in the liver and to some extent in the lungs.

Biological function summary

Cytochrome P450 enzymes including 2B1 and 2B2 function to metabolize endogenous and exogenous compounds through monooxygenase activity. 2B1 and 2B2 do not operate in solitude but are involved with the cytochrome P450 complex which includes NADPH-cytochrome P450 reductase. This complex plays an integral role in enabling the metabolism of a wide variety of substrates such as steroids fatty acids and xenobiotics.

Pathways

Cytochrome P450 2B1 and 2B2 take part in the metabolic pathway of xenobiotics and various drugs. These pathways include hydroxylation processes necessary for drug detoxification and clearance. In this context CYP2B1 and CYP2B2 interact closely with other proteins like CYP3A4 which also plays a part in drug metabolism within the liver to ensure coordinated metabolic conversion of foreign chemicals.

Associated diseases and disorders

CYP2B1 and CYP2B2 have significance in conditions such as liver disease and certain types of drug-induced toxicity. The enzymes' altered activity can lead to improper drug clearance and toxic buildup contributing to liver disorders. They also have associations with specific proteins like GST (glutathione S-transferases) that aid in detoxification and changes in these interactions may exacerbate susceptibility to drug-related liver damage.