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AB22721

Anti-Cytochrome P450 2B1 + 2B2 antibody [b/e4 (9.20)]

5

(2 Reviews)

|

(1 Publication)

Mouse Monoclonal Cytochrome P450 2B1 antibody. Carrier free. Suitable for ELISA, WB, IP and reacts with Rat, Mouse samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Rat Cyp2b1.

View Alternative Names

Cyp2b-1, Cyp2b1, Cytochrome P450 2B1, CYPIIB1, Cytochrome P450-B, Cytochrome P450-LM2, Cytochrome P450-PB1, Cytochrome P450-PB2, Cytochrome P450b

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

b/e4 (9.20)

Isotype

IgG1

Carrier free

Yes

Reacts with

Rat, Mouse

Applications

IP, WB, ELISA

applications

Immunogen

Full Length Protein corresponding to Rat Cyp2b1. The exact immunogen used to generate this antibody is proprietary information.

P00176

Specificity

Clone b/e4 does not react with CYP 1A1, 1A2, 2C6, 2C7, 2C11, 4A2, 4A3.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytochrome P450 2B1 and 2B2 are enzymes that belong to the cytochrome P450 superfamily often referred to as CYP2B1 and CYP2B2 respectively. They are important in drug metabolism and chemical biotransformation. These enzymes have a role in oxidizing organic substances which helps in processing drugs in the liver. Each has a molecular mass of around 54 kDa and shows expression in tissues primarily in the liver and to some extent in the lungs.
Biological function summary

Cytochrome P450 enzymes including 2B1 and 2B2 function to metabolize endogenous and exogenous compounds through monooxygenase activity. 2B1 and 2B2 do not operate in solitude but are involved with the cytochrome P450 complex which includes NADPH-cytochrome P450 reductase. This complex plays an integral role in enabling the metabolism of a wide variety of substrates such as steroids fatty acids and xenobiotics.

Pathways

Cytochrome P450 2B1 and 2B2 take part in the metabolic pathway of xenobiotics and various drugs. These pathways include hydroxylation processes necessary for drug detoxification and clearance. In this context CYP2B1 and CYP2B2 interact closely with other proteins like CYP3A4 which also plays a part in drug metabolism within the liver to ensure coordinated metabolic conversion of foreign chemicals.

CYP2B1 and CYP2B2 have significance in conditions such as liver disease and certain types of drug-induced toxicity. The enzymes' altered activity can lead to improper drug clearance and toxic buildup contributing to liver disorders. They also have associations with specific proteins like GST (glutathione S-transferases) that aid in detoxification and changes in these interactions may exacerbate susceptibility to drug-related liver damage.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
See full target information Cyp2b1

Additional targets

Cyp2b2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Toxicological sciences : an official journal of the Society of Toxicology 137:350-70 PubMed24235770

2013

Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies.

Applications

WB

Species

Rat

Philip M E Probert,Git W Chung,Simon J Cockell,Loranne Agius,Pasquale Mosesso,Steven A White,Fiona Oakley,Colin D A Brown,Matthew C Wright
View all publications
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Alternative Products

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Product promise

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