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AB198870

Anti-Cytochrome P450 2B6/CYP2B6 antibody

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(1 Publication)

Rabbit Polyclonal Cytochrome P450 2B6/CYP2B6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Cytochrome P450 2B6.

View Alternative Names

Cytochrome P450 2B6, CYPIIB6, Cytochrome P450 IIB1, CYP2B6

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling Cytochrome P450 2B6/CYP2B6 with ab198870 at 1/25 dilution.

Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)
  • WB

Supplier Data

Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)

Gel : 8% SDS-PAGE

All lanes:

Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody (ab198870) at 1/400 dilution

All lanes:

Human colon cancer tissue lysate at 40 µg

Predicted band size: 56 kDa

false

Exposure time: 4min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human Cytochrome P450 2B6. The exact immunogen used to generate this antibody is proprietary information.

P20813

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Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody [EPR9985(B)] (AB140609)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytochrome P450 2B6 (CYP2B6) an essential enzyme in the cytochrome P450 superfamily plays a role in the metabolism of various substances. Often referred to as CYP2B6 or P450 2B6 this enzyme has a molecular mass of approximately 56 kDa. CYP2B6 is predominantly expressed in the liver but also found in the brain and testes. It catalyzes oxidation reactions thereby affecting the biotransformation of endogenous and exogenous compounds including drugs and steroids.
Biological function summary

CYP2B6 is involved in metabolizing drugs and synthesizing cholesterol steroids and other lipids. It forms part of a broader enzymatic complex that facilitates these biochemical reactions. As a monooxygenase it introduces an oxygen atom into its substrates contributing to drug metabolism and clearance from the body. This function aids detoxification processes and supports homeostasis.

Pathways

CYP2B6 is integral to the metabolism of xenobiotics and drug biotransformation pathways. It closely interacts with other cytochrome P450 enzymes such as CYP3A4 in these pathways. During drug metabolism these enzymes can affect the pharmacokinetics and pharmacodynamics of various pharmaceutical agents influencing their efficacy and toxicity.

CYP2B6 shows a connection with drug-induced liver injury and certain neurological disorders. Genetic polymorphisms in CYP2B6 can affect its function leading to variability in drug metabolism between individuals. This can contribute to adverse drug reactions or altered therapeutic effects. The enzyme's interaction with proteins like CYP2D6 relates to altered responses to antidepressants impacting treatment outcomes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed : 12865317, PubMed : 21289075). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed : 21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed : 12865317, PubMed : 21289075). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed : 11695850, PubMed : 22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed : 11695850).. Allele 2B6*9 : Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
See full target information Cytochrome P450 2B6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Aging and disease 15:804-823 PubMed37611899

2023

Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Feiyan Zhao,Long Yan,Xuehan Zhao,Jiaqi Wu,Ying Fang,Zhimin Xin,Hongmei Wang,Xiaokui Yang
View all publications
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Product promise

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