Anti-Cytochrome P450 2B6/CYP2B6 antibody [EPR9985(B)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cytochrome P450 2B6 (CYP2B6) an essential enzyme in the cytochrome P450 superfamily plays a role in the metabolism of various substances. Often referred to as CYP2B6 or P450 2B6 this enzyme has a molecular mass of approximately 56 kDa. CYP2B6 is predominantly expressed in the liver but also found in the brain and testes. It catalyzes oxidation reactions thereby affecting the biotransformation of endogenous and exogenous compounds including drugs and steroids.

Biological function summary

CYP2B6 is involved in metabolizing drugs and synthesizing cholesterol steroids and other lipids. It forms part of a broader enzymatic complex that facilitates these biochemical reactions. As a monooxygenase it introduces an oxygen atom into its substrates contributing to drug metabolism and clearance from the body. This function aids detoxification processes and supports homeostasis.

Pathways

CYP2B6 is integral to the metabolism of xenobiotics and drug biotransformation pathways. It closely interacts with other cytochrome P450 enzymes such as CYP3A4 in these pathways. During drug metabolism these enzymes can affect the pharmacokinetics and pharmacodynamics of various pharmaceutical agents influencing their efficacy and toxicity.

Associated diseases and disorders

CYP2B6 shows a connection with drug-induced liver injury and certain neurological disorders. Genetic polymorphisms in CYP2B6 can affect its function leading to variability in drug metabolism between individuals. This can contribute to adverse drug reactions or altered therapeutic effects. The enzyme's interaction with proteins like CYP2D6 relates to altered responses to antidepressants impacting treatment outcomes.