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AB180597

Anti-Cytochrome P450 Reductase antibody [EPR14479(B)]

  • BOND RX™ Validated
  • RabMAb
  • Recombinant
  • KO Validated
  • 20ul selling size
  • What is this?

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(12 Publications)

Rabbit Recombinant Monoclonal Cytochrome P450 Reductase antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Mouse, Rat, Human samples. Cited in 12 publications.

View Alternative Names

CYPOR, POR, NADPH--cytochrome P450 reductase, CPR, P450R

13 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Immunohistochemical analysis of paraffin embedded Human infiltrating duct carcinoma of breast tissue labeling Cytochrome P450 Reductase with ab180597 at a 1/150 dilution. HRP Polymer for Rabbit IgG secondary used. Counterstained with Hematoxylin.

Perform heat mediated antigen retrieval with EDTA buffer pH 9 before commencing with IHC staining protocol.

Immunocytochemistry/ Immunofluorescence - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Immunofluorescence analysis of MCF7 cells (fixative 4% paraformaldehyde) labeling Cytochrome P450 Reductase with ab180597 at a 1/100 dilution (green), and counterstained with Dapi (blue). Goat anti rabbit IgG (Dylight 555) secondary used at a 1/200 diution.

Flow Cytometry (Intracellular) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Intracellular Flow Cytometry analysis of HeLa cells using ab180597 at a 1/10 dilution (red) and a rabbit IgG as negative control (green). Goat anti rabbit IgG (FITC) secondary usedat a 1/150 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Immunocytochemistry/Immunofluorescence analysis of HeLa (Human epithelial cell line from cervix adenocarcinoma) labeling Cytochrome P450 Reductase with purified ab180597 at 1/500 dilution. Cells were fixed with 100% methanol. ab150077 Goat anti rabbit IgG (Alexa Fluor® 488) at 1/1000 was used as the secondary antibody. Nuclei were counterstained with DAPI. PBS was used instead of the primary antibody as the negative control.

Immunocytochemistry/ Immunofluorescence - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Immunofluorescence analysis of Hela cells (fixative 4% paraformaldehyde) labeling Cytochrome P450 Reductase with ab180597 at a 1/100 dilution (red), and counterstained with Dapi (blue). Goat anti rabbit IgG (Dylight 555) secondary used at a 1/200 diution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Immunohistochemical analysis of paraffin-embedded Rat kidney tissue labelling Cytochrome P450 Reductase with ab180597 at 1/1000 (0.1 μg/ml) followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection).The section was counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection). Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins. Postive staining on rat kidney. The section was incubated with ab180597 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Immunohistochemical analysis of paraffin-embedded Mouse kidney tissue labelling Cytochrome P450 Reductase with ab180597 at 1/1000 (0.1 μg/ml) followed by a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection).The section was counterstained with Hematoxylin. Secondary antibody only control : Secondary antibody is a ready to use LeicaDS9800 (Bond™ Polymer Refine Detection). Heat mediated antigen retrieval was performed with Tris-EDTA buffer (pH 9.0, Epitope Retrieval Solution2) for 20 mins. Postive staining on mouse kidney. The section was incubated with ab180597 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument.

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • WB

Lab

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

ab180597 Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] was shown to specifically react with Cytochrome P450 Reductase in HeLa wild-type cells ( ab255448). Loss of signal was observed when knockout cell line ab264996 (knockout cell lysate ab257595) was used. Wild-type and Cytochrome P450 Reductase knockout samples were subjected to SDS-PAGE. ab180597 and Anti-GAPDH antibody [6C5] - Loading Control (ab8245) were incubated overnight at 4°C at 1 in 10000 dilution and 1 in 20000 dilution respectively. Blots were developed with Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed (ab216773) and Goat anti-Mouse IgG H&L (IRDye® 680RD) preadsorbed (ab216776) secondary antibodies at 1 in 20000 dilution for 1 hour at room temperature before imaging.

All lanes:

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (ab180597) at 1/10000 dilution

Lane 1:

Wild-type HeLa lysate at 20 µg

Lane 2:

Cytochrome P450 Reductase knockout HeLa lysate at 20 µg

Lane 2:

Western blot - Human POR (Cytochrome P450 Reductase) knockout HeLa cell line (<a href='/en-us/products/cell-lines/human-por-cytochrome-p450-reductase-knockout-hela-cell-line-ab264996'>ab264996</a>)

Lane 3:

HepG2 lysate at 20 µg

Lane 4:

A431 lysate at 20 µg

Predicted band size: 76 kDa

false

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • WB

Lab

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Lanes 1- 4 : Merged signal (red and green). Green - ab180597 observed at 80 kDa. Red - Anti-GAPDH antibody [6C5] - Loading Control (ab8245) observed at 37 kDa.

ab180597 was shown to react with Cytochrome P450 Reductase in wild-type HCT116 cells in western blot. Loss of signal was observed when knockout cell line ab266889 (knockout cell lysate ab257596) was used. Wild-type HCT116 and POR knockout HCT116 cell lysates were subjected to SDS-PAGE. Membrane was blocked for 1 hour at room temperature in 0.1% TBST with 3% non-fat dried milk. ab180597 and Anti-GAPDH antibody [6C5] - Loading Control (ab8245) overnight at 4°C at a 1 in 1000 dilution and a 1 in 20000 dilution respectively. Blots were developed with Goat anti-Rabbit IgG H&L (IRDye®800CW) preadsorbed (ab216773) and Goat anti-Mouse IgG H&L (IRDye®680RD) preadsorbed (ab216776) secondary antibodies at 1 in 20000 dilution for 1 hour at room temperature before imaging.

All lanes:

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (ab180597) at 1/1000 dilution

Lane 1:

Wild-type HCT116 cell lysate at 40 µg

Lane 2:

POR knockout HCT116 cell lysate at 40 µg

Lane 2:

Western blot - Human POR (Cytochrome P450 Reductase) knockout HCT116 cell line (<a href='/en-us/products/cell-lines/human-por-cytochrome-p450-reductase-knockout-hct116-cell-line-ab266889'>ab266889</a>)

Lane 3:

HepG2 cell lysate at 40 µg

Lane 4:

A431 cell lysate at 40 µg

Predicted band size: 76 kDa

Observed band size: 80 kDa

false

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • WB

Supplier Data

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

All lanes:

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (ab180597) at 1/10000 dilution

Lane 1:

HeLa lysate at 20 µg

Lane 2:

MCF7 lysate at 20 µg

Lane 3:

A431 lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L) Peroxidase conjugated at 1/1000 dilution

Predicted band size: 76 kDa

false

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • WB

Lab

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Blocking and diluting buffer and concentration : 5% NFDM/TBST. Exposure time : Lane 1-3 : 26 seconds; Lane 4-7 : 75 seconds. The identities of the lower MW bands between 37 and 60kDa are unknown.

All lanes:

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (ab180597) at 1/1000 dilution

Lane 1:

Mouse brain tissue lysate at 20 µg

Lane 2:

Mouse heart tissue lysate at 20 µg

Lane 3:

Mouse spleen tissue lysate at 20 µg

Lane 4:

Mouse kidney tissue lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 76 kDa

Observed band size: 75 kDa

false

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • WB

Lab

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

Blocking and diluting buffer and concentration : 5% NFDM/TBST. Exposure time : Lane 1-3 : 26 seconds; Lane 4-7 : 75 seconds. The identities of the lower MW bands between 37 and 60kDa are unknown.

All lanes:

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (ab180597) at 1/1000 dilution

Lane 1:

Rat brain tissue lysate at 20 µg

Lane 2:

Rat heart tissue lysate at 20 µg

Lane 3:

Rat spleen tissue lysate at 20 µg

Lane 4:

Rat kidney tissue lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 76 kDa

Observed band size: 75 kDa

false

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)
  • WB

Supplier Data

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (AB180597)

All lanes:

Western blot - Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] (ab180597) at 1/50000 dilution

All lanes:

HepG2 lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (H+L) Peroxidase conjugated at 1/1000 dilution

Predicted band size: 76 kDa

false

  • Carrier free

    Anti-Cytochrome P450 Reductase antibody [EPR14479(B)] - BSA and Azide free

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Cytochrome P450 Reductase antibody [EPR14479(B)]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14479(B)

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

Flow Cyt (Intra), WB, IHC-P, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p><strong>For unpurified use at 1/100.</strong></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10", "FlowCytIntra-species-notes": "<p><a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p>Heat up to 98 °C, below boiling, and then let cool for 10-20 min.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p>Heat up to 98 °C, below boiling, and then let cool for 10-20 min.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p>Heat up to 98 °C, below boiling, and then let cool for 10-20 min.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }

Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytochrome P450 reductase also known as NADPH--cytochrome P450 reductase (CPR) is an enzyme important in electron transfer. It has a mass of approximately 77 kDa and is responsible for transferring electrons from NADPH to cytochrome P450 enzymes supporting their function. The enzyme is predominantly expressed in the endoplasmic reticulum of liver cells and other tissues where detoxification processes occur. Cytochrome reductase as it is sometimes called plays a fundamental role in the metabolism of drugs and the synthesis of cholesterol steroids and other lipids.
Biological function summary

CPR facilitates electron donation to all microsomal cytochrome P450 enzymes which are involved in a variety of oxidative reactions. This protein is essential for P450 activity assay as it is part of a multienzyme complex that metabolizes exogenous and endogenous compounds efficiently. Without cytochrome P450 reductase the catalytic activity of cytochrome P450 enzymes becomes impaired affecting metabolizing mechanisms for various substances and having systemic biological impacts.

Pathways

Cytochrome P450 reductase directly participates in drug metabolism and steroid biosynthesis pathways. It together with the cytochrome P450 enzymes metabolizes drugs to make them more water-soluble for excretion. The proteins 3 beta-hydroxysteroid dehydrogenase and CYP3A4 are some of the related components within these pathways working in conjunction to achieve metabolic homeostasis. P450 reductase assays are often utilized to study these pathways further understanding the biological roles and interactions of these proteins.

CPR has a significant connection to conditions like congenital adrenal hyperplasia and prostate cancer. Mutations or dysregulations in cytochrome P450 reductase can lead to accumulated steroid precursors and disrupted steroid hormone synthesis contributing to these disorders. The relationship with adrenal enzyme 21-hydroxylase and the androgen receptor illustrates the pathway complexities and the clinical relevance of cytochrome P450 reductase. Understanding these connections highlights the importance of CPR in maintaining normal physiological functions and how its abnormalities can lead to serious health issues.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
See full target information POR

Publications (12)

Recent publications for all applications. Explore the full list and refine your search

Nature 645:1011-1019 PubMed40804518

2025

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury.

Applications

Unspecified application

Species

Unspecified reactive species

Wulf Tonnus,Francesca Maremonti,Shubhangi Gavali,Marlena Nastassja Schlecht,Florian Gembardt,Alexia Belavgeni,Nadja Leinung,Karolin Flade,Natalie Bethe,Sofia Traikov,Anne Haag,Danny Schilling,Sider Penkov,Melodie Mallais,Christine Gaillet,Claudia Meyer,Melika Katebi,Anushka Ray,Louisa M S Gerhardt,Anne Brucker,Jorunn Naila Becker,Mirela Tmava,Lisa Schlicker,Almut Schulze,Nina Himmerkus,Andrej Shevchenko,Mirko Peitzsch,Uladzimir Barayeu,Sonia Nasi,Juliane Putz,Kenneth S Korach,Joel Neugarten,Ladan Golestaneh,Christian Hugo,Jan Ulrich Becker,Joel M Weinberg,Svenja Lorenz,Bettina Proneth,Marcus Conrad,Eckhard Wolf,Bernd Plietker,Raphaël Rodriguez,Derek A Pratt,Tobias P Dick,Maria Fedorova,Stefan R Bornstein,Andreas Linkermann

Biological & pharmaceutical bulletin 47:1422-1428 PubMed39111864

2024

Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.

Applications

Unspecified application

Species

Unspecified reactive species

Ryosuke Negoro,Ayu Ouchi,Sayaka Deguchi,Kazuo Takayama,Takuya Fujita

Science advances 10:eadk7329 PubMed38489367

2024

Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Anne von Mässenhausen,Marlena Nastassja Schlecht,Kristina Beer,Francesca Maremonti,Wulf Tonnus,Alexia Belavgeni,Shubhangi Gavali,Karolin Flade,Joel S Riley,Nadia Zamora Gonzalez,Anne Brucker,Jorunn Naila Becker,Mirela Tmava,Claudia Meyer,Mirko Peitzsch,Christian Hugo,Florian Gembardt,Jose Pedro Friedmann Angeli,Stefan R Bornstein,Stephen W G Tait,Andreas Linkermann

Cellular and molecular gastroenterology and hepatology 13:1649-1672 PubMed35202887

2022

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Sha Huang,Yuhua Wang,Shuwen Xie,Yuqi Lai,Chan Mo,Ting Zeng,Shanshan Kuang,Guanghui Deng,Chuying Zhou,Yuyao Chen,Shaohui Huang,Lei Gao,Zhiping Lv

International journal of molecular sciences 23: PubMed35054909

2022

Hippocampal Expression of Cytochrome P450 1B1 in Penetrating Traumatic Brain Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Erik Lidin,Mattias K Sköld,Maria Angéria,Johan Davidsson,Mårten Risling

Cell chemical biology 29:157-170.e6 PubMed34813762

2021

PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ.

Applications

Unspecified application

Species

Unspecified reactive species

Fengxiang Wang,Emily T Graham,Nathchar Naowarojna,Zhennan Shi,Yuqi Wang,Guanglei Xie,Lili Zhou,Wendy Salmon,Jie-Min Jia,Xi Wang,Yuwei Huang,Stuart L Schreiber,Yilong Zou

PLoS pathogens 17:e1009927 PubMed34516571

2021

Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology.

Applications

Unspecified application

Species

Unspecified reactive species

Salimata Bagayoko,Stephen Adonai Leon-Icaza,Miriam Pinilla,Audrey Hessel,Karin Santoni,David Péricat,Pierre-Jean Bordignon,Flavie Moreau,Elif Eren,Aurélien Boyancé,Emmanuelle Naser,Lise Lefèvre,Céline Berrone,Nino Iakobachvili,Arnaud Metais,Yoann Rombouts,Geanncarlo Lugo-Villarino,Agnès Coste,Ina Attrée,Dara W Frank,Hans Clevers,Peter J Peters,Céline Cougoule,Rémi Planès,Etienne Meunier

Nature chemical biology 17:501 PubMed33654315

2021

Author Correction: Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yilong Zou,Haoxin Li,Emily T Graham,Amy A Deik,John K Eaton,Wenyu Wang,Gerardo Sandoval-Gomez,Clary B Clish,John G Doench,Stuart L Schreiber

Molecular cell 81:355-369.e10 PubMed33321093

2020

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Yan,Youwei Ai,Qi Sun,Yan Ma,Yang Cao,Jiawen Wang,Zhiyuan Zhang,Xiaodong Wang

Translational psychiatry 9:260 PubMed31624233

2019

Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress.

Applications

Unspecified application

Species

Unspecified reactive species

Min Tang,Haojun Huang,Shuiming Li,Mi Zhou,Zhao Liu,Rongzhong Huang,Wei Liao,Peng Xie,Jian Zhou
View all publications

Product promise

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