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AB9383

Anti-Cytokeratin 10 + 13 antibody [DE-K13]

4

(2 Reviews)

|

(1 Publication)

Mouse Monoclonal Cytokeratin 10 antibody. Suitable for IHC-Fr and reacts with Zebrafish samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human KRT10.

View Alternative Names

KPP, KRT10, Cytokeratin-10, Keratin-10, CK-10, K10, Cytokeratin-13, Keratin-13, CK-13, K13, KRT13

1 Images
Immunohistochemistry (Frozen sections) - Anti-Cytokeratin 10 + 13 antibody [DE-K13] (AB9383)
  • IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-Cytokeratin 10 + 13 antibody [DE-K13] (AB9383)

Immunofluorescence staining of a 7 days old zebrafish embryo

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

DE-K13

Isotype

IgG2a

Light chain type

kappa

Carrier free

No

Reacts with

Zebrafish

Applications

IHC-Fr

applications

Immunogen

Full Length Protein corresponding to Human KRT10. The exact immunogen used to generate this antibody is proprietary information.

P13645

Specificity

This antibody reacts with cytokeratin 10 and 13 in fixed cells and frozen tissue, but exclusively with cytokeratin 13 in formalin fixed paraffin embedded tissue.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Reacts with cytokeratin 10 and 13 in frozen tissues.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 10 and 13 also known as CK10 and CK13 are intermediate filament proteins part of the keratin family. Cytokeratin 10 has a molecular mass of approximately 59 kDa while cytokeratin 13 weighs about 53 kDa. Expression of these proteins occurs mainly in the stratified epithelium like that found in the epidermis and certain mucosal tissues. Their mechanical role includes maintaining structural integrity and providing resilience to epithelial cells against mechanical stress.
Biological function summary

Cytokeratin 10 and 13 play important roles in the differentiation and development of epithelial tissues. As components of the cytoskeletal network they aid in cell adhesion migration and intracellular signaling. These proteins integrate into a complex of intermediate filaments that support cellular architecture collaborating with other cytokeratins to sustain cellular framework.

Pathways

Cytokeratin 10 and 13 participate in the keratinization process essential for skin homeostasis. They are integral to the epidermal differentiation complex which includes interactions with proteins like loricrin and filaggrin. These pathways ensure proper formation of the skin barrier and prevent water loss maintaining skin's protective function.

Cytokeratin 10 and 13 are associated with conditions such as Ichthyosis with confetti and oral cancer. Altered expression or mutations can lead to disruptions in epithelial differentiation contributing to disease pathogenesis. Their involvement with proteins like p63 and other keratins links them to hereditary skin disorders where impaired regulation of the keratinocyte life cycle manifests as clinical symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity).. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
See full target information KRT10

Additional targets

Keratin, type I cytoskeletal 13
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Mucosal immunology 6:776-86 PubMed23187317

2012

The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages.

Applications

Unspecified application

Species

Human

Y Ganor,Z Zhou,J Bodo,D Tudor,J Leibowitch,D Mathez,A Schmitt,M-C Vacher-Lavenu,M Revol,M Bomsel
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Product promise

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