AB220193

Anti-Cytokeratin 19 antibody [KRT19/800]

Name: Anti-Cytokeratin 19 antibody [KRT19/800] (ab220193) | Abcam
Brand: Abcam Limited
SKU: AB220193
Price: 510 USD
Availability: InStock
Rating: 5 (2 reviews)

(2 Reviews)

(11 Publications)

Mouse Monoclonal Cytokeratin 19 antibody. Suitable for ICC, WB, IHC-P and reacts with Human, Rat samples. Cited in 11 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KRT19.

View Alternative Names

Cytokeratin-19, Keratin-19, CK-19, K19, KRT19, ck19, ck 19

9 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human bladder carcinoma tissue labeling Cytokeratin 19 with ab220193 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human ovarian carcinoma tissue labeling Cytokeratin 19 with ab220193 at 1 μg/ml dilution.

Supplier Data

Immunocytochemistry - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunocytochemistry analysis of MeOH fixed MCF7 (human breast adenocarcinoma cell line) cells labeling CK19 using ab220193 followed by Goat anti-mouse IgG-CF488 (Cyan). The nuclear counterstain is Reddot (Red).

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human endometrial carcinoma tissue labeling Cytokeratin 19 with ab220193 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human pancreas tissue labeling Cytokeratin 19 with ab220193 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat stomach tissue labeling Cytokeratin 19 with ab220193 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat lung tissue labeling Cytokeratin 19 with ab220193 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat colon tissue labeling Cytokeratin 19 with ab220193 at 1 μg/ml dilution.

Supplier Data

Western blot - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

All lanes:

Western blot - Anti-Cytokeratin 19 antibody [KRT19/800] (ab220193)

All lanes:

Human lung lysate

Predicted band size: 44 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

KRT19/800

Isotype

IgG1

Light chain type

kappa

Carrier free

Reacts with

Rat, Human

Applications

IHC-P, WB, ICC

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KRT19.

P08727

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1-2 µg/mL", "ICC-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "Primary incubation for 30 minutes at room temperature. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 minutes." }, "Rat": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "Primary incubation for 30 minutes at room temperature. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 minutes." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Purification notes

ab220193 was purified from Bioreactor Concentrate by Protein A/G.

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 19 (CK19) also known as cytokeratine 19 keratin 19 (KRT19) or CK19 is a type of intermediate filament found in epithelial cells. It serves as an essential component of the cytoskeleton. CK19 weighs approximately 40 kDa and is broadly expressed in simple epithelial tissues including liver intestine and various glandular epithelial cells. As a cytokeratin marker it often appears in combination with others like cytokeratin 17 in certain tissue types helping to maintain the structural integrity of cells.

Biological function summary

CK19 plays a role in maintaining the cytoskeletal framework that provides mechanical support and helps control cell size and shape. It is not part of a large protein complex but works closely with other cytokeratins to ensure the stability and resilience of epithelial tissues. The A53-B/A22.26 positive staining is often used to confirm its presence in clinical histopathology.

Pathways

CK19 connects to cellular processes especially involving the keratinization and epithelial cell differentiation pathways. It interacts with other cytokeratins including BA16 and KR17 to facilitate these processes. This interaction aids in modulating the dynamics of cytoskeletal rearrangement during cell movement division and differentiation.

CK19 overexpression is linked with certain cancers notably hepatocellular carcinoma and breast cancer. It can serve as a prognostic marker in these diseases often in conjunction with other markers like CK17. The involvement of CK19 in the epithelial-mesenchymal transition (EMT) process connects it to the progression and aggressiveness of tumors facilitated by interactions with proteins involved in EMT pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

See full target information KRT19

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

World journal of gastroenterology 31:106949 PubMed40575338

2025

Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Miao-Xin Zhang,Chi Wu,Xin-Xia Feng,Wei Tian,Ning-Hui Zhao,Pan-Pan Lu,Qiang Ding,Mei Liu

Bioactive materials 50:215-231 PubMed40276539

2025

All-in-one extracellular matrix-based powders with instant self-assembly and multiple bioactivities integrate hemostasis and in-situ tissue functional repair.

Applications

Unspecified application

Species

Unspecified reactive species

Chen-Yu Zou,Chen Han,Ming Xiong,Juan-Juan Hu,Yan-Lin Jiang,Xiu-Zhen Zhang,Ya-Xing Li,Long-Mei Zhao,Yu-Ting Song,Qing-Yi Zhang,Qian-Jin Li,Rong Nie,Yue-Qi Zhang,Jesse Li-Ling,Hui-Qi Xie

Viruses 17: PubMed40006917

2025

Ad6-Based GM-CSF Expressing Vector Displays Oncolytic and Immunostimulatory Effects in an Immunocompetent Syrian Hamster Model of Cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Daria S Zabelina,Ivan D Osipov,Denis E Maslov,Anna V Kovner,Valeriia A Vasikhovskaia,Diana S Demina,Stanislav E Romanov,Ekaterina V Shishkina,Julia Davydova,Sergey V Netesov,Margarita V Romanenko

BMC cancer 25:55 PubMed39789507

2025

CK19 protein expression: the best cutoff value on the prognosis and the prognosis model of hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chenglei Yang,Wanyan Xiang,Zongze Wu,Nannan Li,Guoliang Xie,Juntao Huang,Lixia Zeng,Hongping Yu,Bangde Xiang

Cytotechnology 76:415-424 PubMed38933870

2024

Stable two- and three-dimensional cholangiocyte culture systems from extrahepatic bile ducts of biliary atresia patients: use of structural and functional bile duct epithelium models for in vitro analyses.

Applications

Unspecified application

Species

Unspecified reactive species

Ai Shimamura,Mayumi Higashi,Kazuya Nagayabu,Shigeru Ono

The journal of gene medicine 26:e3693 PubMed38860366

2024

Interleukin-17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Sheng Ni,Si-Yuan Fu,Zong-Yan Wang,Wen-Bin Ding,Jian Huang,Xing-Gang Guo,Fang-Ming Gu

Toxins 16: PubMed38535810

2024

Environmental Toxin Biliatresone-Induced Biliary Atresia-like Abnormal Cilia and Bile Duct Cell Development of Human Liver Organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Hai-Bing,Menon Sudheer Sivasankaran,Babu Rosana Ottakandathil,Wu Zhong-Luan,So Man-Ting,Chung Patrick Ho-Yu,Wong Kenneth Kak-Yuen,Tam Paul Kwong-Hang,Lui Vincent Chi-Hang

Frontiers in pediatrics 12:1338131 PubMed38318455

2024

The clinical impact of macrophage polarity after Kasai portoenterostomy in biliary atresia.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuya Nagayabu,Shigehisa Fumino,Ai Shimamura,Yuki Sengoku,Mayumi Higashi,Masafumi Iguchi,Shigeyoshi Aoi,Shibata Saya,Maki Hirai,Hiroshi Ogi,Aya Miyagawa-Hayashino,Eiichi Konishi,Kyoko Itoh,Tatsuro Tajiri,Shigeru Ono

Annals of translational medicine 10:1066 PubMed36330418

2022

Characteristics of pre-sensitization-related acute antibody-mediated rejection in a rat model of orthotopic liver transplantation.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyi Mang,Shengning Zhang,Jiaojiao Zhao,Jianghua Ran,Yingpeng Zhao,Laibang Li,Yang Gao,Wang Li,Guoyu Chen,Jun Ma,Li Li,Fukai Bao

Cell reports 29:1832-1847.e8 PubMed31722201

2019

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ross Dobie,John R Wilson-Kanamori,Beth E P Henderson,James R Smith,Kylie P Matchett,Jordan R Portman,Karolina Wallenborg,Simone Picelli,Anna Zagorska,Swetha V Pendem,Thomas E Hudson,Minnie M Wu,Grant R Budas,David G Breckenridge,Ewen M Harrison,Damian J Mole,Stephen J Wigmore,Prakash Ramachandran,Chris P Ponting,Sarah A Teichmann,John C Marioni,Neil C Henderson

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Cytokeratin 19 antibody [KRT19/800]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunocytochemistry - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Western blot - Anti-Cytokeratin 19 antibody [KRT19/800] (AB220193)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Product promise