AB212572

Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free

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(1 Publication)

Mouse Monoclonal Cytokeratin 19 antibody. Carrier free. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KRT19.

View Alternative Names

Cytokeratin-19, Keratin-19, CK-19, K19, KRT19, ck19, ck 19

8 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded human ovarian carcinoma tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded human pancreas tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded human endometrial carcinoma tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded human cervical carcinoma tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded human bladder carcinoma tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded rat stomach tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded rat lung tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 19 antibody [KRT19/800] - BSA and Azide free (AB212572)

Formalin-fixed, paraffin-embedded rat colon tissue stained for Cytokeratin 19 using ab212572 at 1 μg/ml in immunohistochemical analysis.

This IHC-P data was generated using the same anti-Cytokeratin 19 antibody clone, KRT19/800, in a different buffer formulation (cat# ab220193).

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

KRT19/800

Isotype

IgG1

Light chain type

kappa

Carrier free

Yes

Reacts with

Rat, Human

Applications

IHC-P

Immunogen

Recombinant Full Length Protein corresponding to Human KRT19.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 min at RT).</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 min at RT).</p>" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Purification notes

ab212572 was purified from Bioreactor Concentrate by Protein A/G.

Storage buffer

pH: 7.2 - 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 19 (CK19) also known as cytokeratine 19 keratin 19 (KRT19) or CK19 is a type of intermediate filament found in epithelial cells. It serves as an essential component of the cytoskeleton. CK19 weighs approximately 40 kDa and is broadly expressed in simple epithelial tissues including liver intestine and various glandular epithelial cells. As a cytokeratin marker it often appears in combination with others like cytokeratin 17 in certain tissue types helping to maintain the structural integrity of cells.

Biological function summary

CK19 plays a role in maintaining the cytoskeletal framework that provides mechanical support and helps control cell size and shape. It is not part of a large protein complex but works closely with other cytokeratins to ensure the stability and resilience of epithelial tissues. The A53-B/A22.26 positive staining is often used to confirm its presence in clinical histopathology.

Pathways

CK19 connects to cellular processes especially involving the keratinization and epithelial cell differentiation pathways. It interacts with other cytokeratins including BA16 and KR17 to facilitate these processes. This interaction aids in modulating the dynamics of cytoskeletal rearrangement during cell movement division and differentiation.

CK19 overexpression is linked with certain cancers notably hepatocellular carcinoma and breast cancer. It can serve as a prognostic marker in these diseases often in conjunction with other markers like CK17. The involvement of CK19 in the epithelial-mesenchymal transition (EMT) process connects it to the progression and aggressiveness of tumors facilitated by interactions with proteins involved in EMT pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

See full target information KRT19

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 12:4906 PubMed34385456

2021

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kenneth H Gouin,Nathan Ing,Jasmine T Plummer,Charles J Rosser,Bassem Ben Cheikh,Catherine Oh,Stephanie S Chen,Keith Syson Chan,Hideki Furuya,Warren G Tourtellotte,Simon R V Knott,Dan Theodorescu

View all publications

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Product promise

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