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AB16111

Anti-Cytokeratin 2 antibody [AE3]

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(1 Publication)

Mouse Monoclonal Cytokeratin 2P antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KRT2B, KRT2P, KRT76, Cytokeratin-2P, Keratin-76, Type-II keratin Kb9, CK-2P, K2P, K76

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 2 antibody [AE3] (AB16111)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 2 antibody [AE3] (AB16111)

ab16111 staining Cytokeratin 2 in Human kidney tissue using Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

AE3

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Specificity

This antibody is specific for all basic (type II) human keratins K1, K2, K3, K4, K5, K6, K7 and K8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 2 also known as KRT2 is a type II cytokeratin with a molecular weight of approximately 66 kDa. This protein is primarily expressed in the suprabasal layers of the epidermis especially in the upper spinous and granular layers of the skin. KRT2 plays a role in forming and maintaining the structural integrity of the epithelial cells due to its ability to assemble into intermediate filaments that provide mechanical support and resilience to epithelial tissues.
Biological function summary

Cytokeratin 2 contributes to epidermal differentiation and the formation of the skin barrier. It acts as part of the cytoskeletal network in keratinocytes providing structural support to the cells. Cytokeratin 2 is often found operating together with other keratin proteins as part of a complex. Its filamentous structure helps resist stress and external forces allowing the skin to withstand physical and chemical insults.

Pathways

Cytokeratin 2 has a significant role in keratinocyte differentiation and the skin barrier formation pathways. It is intricately related to other members of the keratin family such as Cytokeratin 1 (KRT1) which further regulate these processes. Cytokeratin 2 expression affects pathways that control cell proliferation and apoptosis within the skin ensuring the balance between cell division and cell death necessary for maintaining healthy skin tissue.

Deficiencies or mutations in Cytokeratin 2 can lead to Ichthyosis Bullosa of Siemens a condition characterized by blistering and peeling skin. Mutations may affect the stability and assembly of keratin filaments compromising skin integrity. Cytokeratin 2 abnormalities connect with other cytokeratin proteins like KRT1 which also contribute to similar skin disorders. Understanding its role and interactions with other proteins may assist in the development of treatments for keratin-associated skin diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Probably contributes to terminal cornification.
See full target information KRT76
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of hyperthermia : the offici 36:383-393 PubMed30909744

2019

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Zhe Sun,Jia-Feng Li,Zhen-Dong Wei,Hang-Hang Jiang,Yu-Xiao Hong,Song Zheng,Rui-Qun Qi,Xing-Hua Gao
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