Anti-Cytokeratin 20 antibody [KRT20/1993]
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Mouse Monoclonal Cytokeratin 20 antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KRT20 aa 150-350.
View Alternative Names
Cytokeratin-20, Keratin-20, Protein IT, CK-20, K20, KRT20
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 20 antibody [KRT20/1993] (AB268107)
Formalin-fixed, paraffin-embedded human colon carcinoma tissue stained for Cytokeratin 20 using ab268107 at 2 μg/ml in immunohistochemical analysis.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 20 antibody [KRT20/1993] (AB268107)
Formalin-fixed, paraffin-embedded human normal colon tissue stained for Cytokeratin 20 using ab268107 at 2 μg/ml in immunohistochemical analysis.
- WB
Unknown
Western blot - Anti-Cytokeratin 20 antibody [KRT20/1993] (AB268107)
All lanes:
Western blot - Anti-Cytokeratin 20 antibody [KRT20/1993] (ab268107) at 2 µg/mL
All lanes:
HT29 (Human colorectal adenocarcinoma cell line) cell lysate
Predicted band size: 48 kDa
false
- Protein Array
Unknown
Protein Array - Anti-Cytokeratin 20 antibody [KRT20/1993] (AB268107)
Protein Array containing more than 19,000 full-length human proteins using ab268107.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
Properties and storage information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Cytokeratin 20 is essential in cellular differentiation and maintenance within epithelial tissues. It plays an important role in the structural framework of epithelial cells by integrating into the cytoskeletal network which includes other keratins. Typically cytokeratin 20 forms heterodimers with keratin 8 contributing to the assembly of intermediate filaments. These interactions maintain cell stability and are involved in cellular processes such as migration and proliferation.
Pathways
Cytokeratin 20 participates in the framework of intermediate filament signaling influencing cell motility and secretion in epithelial tissues. It contributes mainly to the keratinization pathway which is critical in forming a protective barrier in epithelial cells. Additionally it is related to cell adhesion and signalling pathways that are important for tissue integrity. Connections with keratin 8 and other cytoskeletal proteins facilitate signal transduction processes necessary for epithelial homeostasis and response to injury.
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