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AB273891

Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric)

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Rabbit Recombinant Monoclonal Fibrinogen alpha chain antibody. Suitable for ELISA and reacts with Human samples.

View Alternative Names

Fibrinogen alpha chain, FGA

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ELISA - Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (AB273891)
  • ELISA

Supplier Data

ELISA - Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (AB273891)

Binding curve of ab273891 to D-dimer protein. ELISA plate coated with D-dimer protein at a concentration of 5 μg/ml. A 3-fold serial dilution from 10,000 ng/ml was performed using ab273891 (blue curve). For detection, a 1/4000 dilution of HRP-labeled anti-rabbit IgG antibody was used. Rabbit anti-Fluorescein [4-4-20 (enhanced)] antibody was used as a control (orange curve).

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

3B6

Isotype

IgG

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

ELISA

applications

Specificity

Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (ab273891) recognises epitopes that reside between amino acids 86 and 302 in the gamma-chain of fragment D chains of fibrinogen (Fragment D) and other cross-linked fibrin degradation products containing D-Dimer, but no reactivity with Fragment D or E, fibrinogen or fibrinogen degradation products.

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Product details

Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (ab273891) is a chimeric rabbit antibody made using the variable domain sequences of the original murine IgG3 format, for improved compatibility with existing reagents, assays and techniques.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Proclin 300 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
See full target information FGA
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Product promise

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