Rabbit Recombinant Monoclonal Fibrinogen alpha chain antibody. Suitable for ELISA and reacts with Human samples.
Images
![ELISA - Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (AB273891), expandable thumbnail](https://content.abcam.com/products/images/d-dimer-antibody-3b6-rabbit-igg-chimeric-ab273891--elisa-img112640.jpg/_jcr_content/renditions/webp-475.webp "ELISA - Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (AB273891)")
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.02% Proclin 300
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
Reactivity data
Select an application| ELISA | |
|---|---|
| Human | Tested |
ELISA
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Version
Target data
Function
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Alternative names
Fibrinogen alpha chain, FGA
Recommended products
Rabbit Recombinant Monoclonal Fibrinogen alpha chain antibody. Suitable for ELISA and reacts with Human samples.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.02% Proclin 300
Constituents: PBS- Form
- Liquid
- Clonality
- Monoclonal
- Clone number
- 3B6
- Purification technique
- Affinity purification Protein A
- Specificity
Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (ab273891) recognises epitopes that reside between amino acids 86 and 302 in the gamma-chain of fragment D chains of fibrinogen (Fragment D) and other cross-linked fibrin degradation products containing D-Dimer, but no reactivity with Fragment D or E, fibrinogen or fibrinogen degradation products.
- Light chain type
- kappa
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (ab273891) is a chimeric rabbit antibody made using the variable domain sequences of the original murine IgG3 format, for improved compatibility with existing reagents, assays and techniques.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
![ELISA - Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (ab273891), expandable thumbnail](https://content.abcam.com/products/images/d-dimer-antibody-3b6-rabbit-igg-chimeric-ab273891--elisa-img112640.jpg "ELISA - Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (ab273891)")
ELISA - Anti-D-Dimer antibody [3B6] - Rabbit IgG (Chimeric) (ab273891)
Binding curve of ab273891 to D-dimer protein. ELISA plate coated with D-dimer protein at a concentration of 5 μg/ml. A 3-fold serial dilution from 10,000 ng/ml was performed using ab273891 (blue curve). For detection, a 1/4000 dilution of HRP-labeled anti-rabbit IgG antibody was used. Rabbit anti-Fluorescein [4-4-20 (enhanced)] antibody was used as a control (orange curve).
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