Goat Polyclonal DAG1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Dystroglycan aa 550-600.
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Publications
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- The Journal of clinical investigation 131:2021GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPatricia Franzka,Henriette Henze,M Juliane Jung,Svenja Caren Schüler,Sonnhild Mittag,Karina Biskup,Lutz Liebmann,Takfarinas Kentache,José Morales,Braulio Martínez,Istvan Katona,Tanja Herrmann,Antje-Kathrin Huebner,J Christopher Hennings,Susann Groth,Lennart Gresing,Rüdiger Horstkorte,Thorsten Marquardt,Joachim Weis,Christoph Kaether,Osvaldo M Mutchinick,Alessandro Ori,Otmar Huber,Véronique Blanchard,Julia von Maltzahn,Christian A HübnerPubMed 33755596
- BMC medicine 18:82020Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAndriy S Yatsenko et. al.PubMed 31959160
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99.48% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human Dystroglycan aa 550-600. The exact immunogen used to generate this antibody is proprietary information. Database link Q14118
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Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
| Bat | Predicted |
| Cat | Predicted |
| Chicken | Predicted |
| Common marmoset | Predicted |
| Cow | Predicted |
| Dog | Predicted |
| Elephant | Predicted |
| Gorilla | Predicted |
| Hamster | Predicted |
| Horse | Predicted |
| Monkey | Predicted |
| Opossum | Predicted |
| Platypus | Predicted |
| Rabbit | Predicted |
| Turkey | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 5 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Rabbit, Horse, Chicken, Hamster, Cow, Cat, Dog, Turkey, Monkey, Gorilla, Opossum, Common marmoset, Bat, Platypus, Elephant | Dilution info - | Notes - |
Associated Products
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Target data
Function
The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Alpha-dystroglycan. Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5 (By similarity). Beta-dystroglycan. Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity. Alpha-dystroglycan. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:17360738, PubMed:19324387). Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927).
Alternative names
Dystroglycan 1, Dystroglycan, Dystrophin-associated glycoprotein 1
Recommended products
Goat Polyclonal DAG1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Dystroglycan aa 550-600.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 99.48% Tris buffered saline, 0.5% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human Dystroglycan aa 550-600. The exact immunogen used to generate this antibody is proprietary information. Database link Q14118
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle, Store undiluted
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DAG1 antibody (ab136665)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labelling DAG1 with ab136665 at 5µg/ml.
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