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AB177470

Anti-dbx2 antibody [EPR12633(B)]

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(1 Publication)

Rabbit Recombinant Monoclonal DBX2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Homeobox protein DBX2, Developing brain homeobox protein 2, DBX2

1 Images
Western blot - Anti-dbx2 antibody [EPR12633(B)] (AB177470)
  • WB

Supplier Data

Western blot - Anti-dbx2 antibody [EPR12633(B)] (AB177470)

All lanes:

Western blot - Anti-dbx2 antibody [EPR12633(B)] (ab177470) at 1/1000 dilution

Lane 1:

HepG2 lysate at 10 µg

Lane 2:

293T lysate at 10 µg

Lane 3:

HT-1080 lysate at 10 µg

Lane 4:

Fetal kidney lysate at 10 µg

Secondary

All lanes:

Goat-anti-rabbit HRP at 1/2000 dilution

Predicted band size: 36 kDa

true

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12633(B)

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dbx2 also known as developing brain homeobox 2 is a homeodomain-containing transcription factor. This protein has an approximate mass of 37 kDa. Dbx2 is mainly expressed in the developing central nervous system particularly in the neural tube where it plays a role in determining neuronal cell fate. During early development dbx2 participates in the regulation of gene expression that dictates the positioning and specialization of neurons.
Biological function summary

The transcription factor Dbx2 contributes to the differentiation of neuronal progenitor cells. Although not part of a multi-protein complex it interacts with other transcription factors to influence the transcriptional networks required for neurogenesis. Dbx2 orchestrates the precise development of specific neuron types by binding to the regulatory regions of genes responsible for neural differentiation.

Pathways

Dbx2 integrates into the pathways responsible for neural patterning and differentiation particularly the Wnt signaling pathway and the Sonic hedgehog (Shh) pathway. In these pathways Dbx2 interacts with proteins like Gli3 in the Shh pathway to modulate the transcriptional outcomes necessary for the development of the dorsoventral axis in the spinal cord. Dbx2 ensures correct levels of activity in these pathways facilitating organized neurodevelopment.

Research links Dbx2 to developmental abnormalities such as spina bifida a condition resulting from improper closure of the neural tube. Studies also suggest potential connections between alterations in Dbx2 expression and certain neurodevelopmental disorders including autism spectrum disorder. Dbx2’s interactions with Shh pathway components like Gli1 highlight its potential involvement in these disorders through misregulation of critical developmental signals.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Homeobox protein DBX2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 24:103151 PubMed34646989

2021

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Shohei Takaoka,Akiko Yanagiya,Haytham Mohamed Aly Mohamed,Rei Higa,Takaya Abe,Ken-Ichi Inoue,Akinori Takahashi,Patrick Stoney,Tadashi Yamamoto
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com