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AB127185

Anti-Dcp2/TDT antibody

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(1 Publication)

Rabbit Polyclonal Dcp2/TDT antibody. Suitable for WB, IHC-P and reacts with Zebrafish, Drosophila melanogaster, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DCP2 aa 1-200.

View Alternative Names

NUDT20, DCP2, m7GpppN-mRNA hydrolase, Nucleoside diphosphate-linked moiety X motif 20, mRNA-decapping enzyme 2, Nudix motif 20, hDpc

2 Images
Western blot - Anti-Dcp2/TDT antibody (AB127185)
  • WB

Unknown

Western blot - Anti-Dcp2/TDT antibody (AB127185)

10% SDS PAGE

All lanes:

Western blot - Anti-Dcp2/TDT antibody (ab127185) at 1/1000 dilution

All lanes:

IMR32 whole cell lysate at 30 µg

Predicted band size: 48 kDa

false

Western blot - Anti-Dcp2/TDT antibody (AB127185)
  • WB

Supplier Data

Western blot - Anti-Dcp2/TDT antibody (AB127185)

Samples were separated by 10% SDS-PAGE.

All lanes:

Western blot - Anti-Dcp2/TDT antibody (ab127185) at 1/500 dilution

All lanes:

24hr whole zebrafish lysate at 30 µg

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Zebrafish, Drosophila melanogaster

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DCP2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q8IU60

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Drosophila melanogaster": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed : 12218187, PubMed : 12417715, PubMed : 12923261, PubMed : 21070968, PubMed : 28002401, PubMed : 31875550). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed : 12486012, PubMed : 12923261, PubMed : 21070968, PubMed : 28002401, PubMed : 31875550). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed : 14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed : 18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed : 21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed : 21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed : 28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed : 26098573).
See full target information DCP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 32: PubMed40709397

2025

Pan‑cancer analysis of the carcinogenic role of WSB2 in human tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Yingzi Deng,Yifei Li,Ruobing Li,Xiaohui Guo,Yan Liu,Shuqing Wang,Juan Zhang,Mi Li,Lina Zhao,Haifeng Cai,Yunfeng Zhang,Fen Hu
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Product promise

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