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AB191096

Anti-DDIT4L/REDD2 antibody [DDIT-03] - N-terminal

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(2 Publications)

Mouse Monoclonal DDIT4L/REDD2 antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DDIT4L aa 1-100.

View Alternative Names

REDD2, RTP801L, DDIT4L, DNA damage-inducible transcript 4-like protein, HIF-1 responsive protein RTP801-like, Protein regulated in development and DNA damage response 2, REDD-2

1 Images
Western blot - Anti-DDIT4L/REDD2 antibody [DDIT-03] - N-terminal (AB191096)
  • WB

Supplier Data

Western blot - Anti-DDIT4L/REDD2 antibody [DDIT-03] - N-terminal (AB191096)

All lanes:

Western blot - Anti-DDIT4L/REDD2 antibody [DDIT-03] - N-terminal (ab191096)

Lane 1:

HEK293 transfected with DDIT4L plasmid

Lane 2:

Untransfected HEK293

Predicted band size: 22 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

DDIT-03

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human DDIT4L aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q96D03

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
ab191096 was purified from cell culture supernatant. Purity: > 95% (by SDS-PAGE).
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DDIT4L/REDD2 protein known alternatively as DDIT is a member of the DNA damage-inducible transcript family with a molecular mass of approximately 23 kDa. It is encoded by the DDIT4L gene and is expressed in multiple tissues with higher expression levels in muscle and fat tissues. This protein plays a role in cellular stress responses and has been associated with the regulation of cell growth and apoptosis.
Biological function summary

DDIT4L/REDD2 influences response to cellular stress signals and acts as an inhibitor of the mTOR pathway—an essential regulator of cell metabolism growth and proliferation. It does not function as part of a large complex but interacts with other proteins to mediate its effects. By inhibiting mTOR activity DDIT4L can affect protein synthesis and autophagy reflecting its role in maintaining cellular homeostasis under stress conditions.

Pathways

DDIT4L/REDD2 is intricately involved in the mTOR signaling cascade and influences the PI3K/AKT pathway two important pathways in cellular metabolism. Within these pathways it is related to proteins like TSC2 (Tuberous Sclerosis Complex 2) and AKT. DDIT4L exerts its effect by modulating signal transduction that impacts cell survival and stress responses making it an important player in the adaptation to environmental changes.

Alterations in DDIT4L/REDD2 expression are implicated in conditions such as cancer and metabolic syndromes. Aberrant regulation of this protein may lead to unchecked cell proliferation or metabolic imbalances involving proteins like mTOR and TSC2. These associations highlight the role of DDIT4L/REDD2 in the maintenance of normal cellular functions and its potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
See full target information DDIT4L
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Publications (2)

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NAR cancer 7:zcaf026 PubMed40918647

2025

Anti-tumorigenic properties by trichothiodystrophy mutations in melanocytic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Rupesh Paudel,Lena F Sorger,Anita Hufnagel,Mira Pasemann,Tamsanqa Hove,André Marquardt,Susanne Kneitz,Andreas Schlosser,Caroline Kisker,Jochen Kuper,Svenja Meierjohann

Nutrients 14: PubMed36297046

2022

Kelulut Honey Improves Folliculogenesis, Steroidogenic, and Aromatase Enzyme Profiles and Ovarian Histomorphology in Letrozole-Induced Polycystic Ovary Syndrome Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Datu Agasi Mohd Kamal,Siti Fatimah Ibrahim,Azizah Ugusman,Siti Sarah Mohamad Zaid,Mohd Helmy Mokhtar
View all publications
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Product promise

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