Anti-DDX59 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DDX59 also known as DEAD box protein 59 is an RNA helicase with an approximate mass of 66 kDa. This protein unwinds RNA duplexes through ATP-dependent mechanism enabling the processing and remodeling of RNA molecules. DDX59 shows expression in various tissues with higher levels observed in the brain and heart indicating its potential importance in these organs.

Biological function summary

DEAD box protein 59 plays a role in RNA metabolism influencing splicing ribosome biogenesis and RNA degradation. DDX59 may function as part of a multi-protein complex working closely with other RNA-binding proteins to regulate RNA structure and function. This regulation is important for gene expression control and proper cell function.

Pathways

DDX59 integrates in critical processes like the RNA splicing pathway and mRNA surveillance pathway. It often collaborates with proteins such as SF3B1 in RNA splicing ensuring the accuracy of mRNA processing. This interaction helps maintain cellular homeostasis and protect against errors in gene expression that might lead to cellular distress or dysfunction.

Associated diseases and disorders

DDX59 has connections to orofaciodigital syndrome type I and neural tube defects. Changes in DDX59 function or expression levels might contribute to these conditions making it a potential biomarker or target for therapeutic interventions. The protein links with other players like DYRK1A in these disorders together affecting neurodevelopment and craniofacial structures.