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AB220684

Anti-DDX60L antibody

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(1 Publication)

Rabbit Polyclonal DDX60L antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DDX60L aa 150-300.

View Alternative Names

Probable ATP-dependent RNA helicase DDX60-like, DEAD box protein 60-like, DDX60L

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-DDX60L antibody (AB220684)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DDX60L antibody (AB220684)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized U-2 OS cells labeling DDX60L with ab220684 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human DDX60L aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q5H9U9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DDX60L also known as DExD/H-box helicase 60-like is a protein involved in the unwinding of RNA molecules. With a mass of approximately 147 kDa it plays a significant role in RNA metabolism. This protein is mostly expressed in immune-related tissues such as the spleen and lymph nodes. DDX60L through its helicase activity binds and processes RNA which impacts the host antiviral response mechanism.
Biological function summary

The functions of DDX60L include sensing viral RNA and activating downstream immune responses. It associates with other similar proteins to form a complex that initiates sensing pathways for RNA viruses. This engagement leads to the activation of innate immune responses which are essential for detecting and responding to infections. DDX60L is part of signaling complexes contributing to the regulation and modulation of immune pathways.

Pathways

DDX60L plays a pivotal role in the RIG-I-like receptor (RLR) signaling pathway. This pathway detects viral RNAs and initiates antiviral responses through interferon production. DDX60L interacts with proteins like RIG-I (retinoic acid-inducible gene I) to regulate the type I interferon signaling pathway enhancing the body's ability to fight viral infections. The protein contributes to maintaining cellular homeostasis under immune stress conditions.

DDX60L is linked to viral infections such as influenza and hepatitis. Its role in the antiviral response makes it a potential target for interventions designed to enhance immune responses against these infections. Additionally the protein's interaction with RIG-I suggests a contributory role in disorders related to dysfunctional immune responses potentially impacting autoimmune conditions where viral components play a part. Understanding DDX60L's function could inform therapeutic approaches to manage these viral-induced disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information DDX60L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 19:313 PubMed31787850

2019

Long noncoding RNA DLX6-AS1 promotes neuroblastoma progression by regulating miR-107/BDNF pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Huan-Yu Zhang,Mao-Qing Xing,Jing Guo,Jin-Chuan Zhao,Xin Chen,Zhong Jiang,Hong Zhang,Qian Dong
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