AB153849

Anti-DECR2/PDCR antibody

Name: Anti-DECR2/PDCR antibody (ab153849) | Abcam
Brand: Abcam Limited
SKU: AB153849
Price: 520 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal DECR2/PDCR antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DECR2 aa 50-250.

View Alternative Names

PDCR, SDR17C1, DECR2, pDCR, Short chain dehydrogenase/reductase family 17C member 1

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-DECR2/PDCR antibody (AB153849)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DECR2/PDCR antibody (AB153849)

Immunocytochemistry/ Immunofluorescence of A549 cells fixed in 4% paraformaldehyde staining DECR2/PDCR using ab153849 at a dilution of 1/500 (green). Nuclear staining with Hoechst 33342 staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DECR2/PDCR antibody (AB153849)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DECR2/PDCR antibody (AB153849)

Immunohistochemical analysis of paraffin-embedded A549 xenograft using ab153849 antibody at 1 : 100 dilution

Unknown

Western blot - Anti-DECR2/PDCR antibody (AB153849)

All lanes:

Western blot - Anti-DECR2/PDCR antibody (ab153849) at 1/1000 dilution

All lanes:

A549 (30 µg of whole cell lysate)

Predicted band size: 31 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human DECR2 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.

Q9NUI1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DECR2 also known as 24-dienoyl-CoA reductase 2 involves in fatty acid metabolism by catalyzing the reduction of unsaturated acyl-CoA compounds. It acts mechanically within the mitochondria allowing the breakdown of polyunsaturated fatty acids. DECR2 weighs approximately 37 kDa and has widespread expression mainly found in tissues with high energy demand like liver heart and muscle.

Biological function summary

DECR2 facilitates the β-oxidation of unsaturated fatty acids therefore supporting energy production. As part of lipid metabolism it helps to maintain cellular energy balance and influences overall energy homeostasis. This enzyme does not form a complex but interacts with other mitochondrial enzymes to synchronize fatty acid degradation processes allowing cells to utilize stored fats efficiently.

Pathways

DECR2 integrates into the fatty acid oxidation pathway which links to energy metabolism pathways providing substrates for ATP production. This enzyme collaborates closely with other molecules like acyl-CoA dehydrogenases and enoyl-CoA isomerases within these pathways. This collaboration ensures the complete breakdown of unsaturated fatty acids influencing both energy production and mitochondrial function.

DECR2 plays an important role in conditions like metabolic syndrome and mitochondrial fatty acid β-oxidation disorders. Abnormalities or deficiencies in its function may contribute to energy metabolism defects impacting cellular energy balance and mitochondrial health. DECR2's activity can associate with other proteins involved in these conditions such as long-chain acyl-CoA dehydrogenase (LCAD) highlighting the need for this enzyme in maintaining metabolic health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

See full target information DECR2

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology research 13:1284-1302 PubMed40512146

2025

Tumor Cell-Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy.

Applications

Unspecified application

Species

Unspecified reactive species

Shuyin Li,Jason W Shapiro,Hardik Shah,Emily F Higgs,Lishi Xie,Yaopeng Li,Yuanyuan Zha,Jonathan Trujillo,Alexandra Cabanov,Tyler A Jones,Blake Flood,Ken Hatogai,Ruxandra Tonea,Justin Kline,Thomas F Gajewski

British journal of cancer 130:741-754 PubMed38216720

2024

Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chui Yan Mah,An Dieu Trang Nguyen,Takuto Niijima,Madison Helm,Jonas Dehairs,Feargal J Ryan,Natalie Ryan,Lake-Ee Quek,Andrew J Hoy,Anthony S Don,Ian G Mills,Johannes V Swinnen,David J Lynn,Zeyad D Nassar,Lisa M Butler

Science signaling 15:eabl9169 PubMed35857633

2022

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Kristoffer H Johansen,Dominic P Golec,Bonnie Huang,Chung Park,Julie H Thomsen,Silvia Preite,Jennifer L Cannons,Fabien Garçon,Edward C Schrom,Christina J F Courrèges,Tibor Z Veres,James Harrison,Meritxell Nus,James D Phelan,Wolfgang Bergmeier,John H Kehrl,Klaus Okkenhaug,Pamela L Schwartzberg

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-DECR2/PDCR antibody

Immunocytochemistry/ Immunofluorescence - Anti-DECR2/PDCR antibody (AB153849)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DECR2/PDCR antibody (AB153849)

Western blot - Anti-DECR2/PDCR antibody (AB153849)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise