AB140039

Anti-Dectin-1 antibody

Name: Anti-Dectin-1 antibody (ab140039) | Abcam
Brand: Abcam Limited
SKU: AB140039
Price: 515 USD
Availability: InStock

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(23 Publications)

Rabbit Polyclonal Dectin-1 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 23 publications. Immunogen corresponding to Synthetic Peptide within Human CLEC7A aa 50-150.

View Alternative Names

CD369, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082, CLEC7A, C-type lectin domain family 7 member A, Beta-glucan receptor, C-type lectin superfamily member 12, Dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, Dectin-1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dectin-1 antibody (AB140039)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dectin-1 antibody (AB140039)

Immunohistochemical analysis of paraffin-embedded Human spleen tissue, labelling Dectin-1 using ab140039 at 5 μg/ml.

Unknown

Western blot - Anti-Dectin-1 antibody (AB140039)

Lane 1:

Western blot - Anti-Dectin-1 antibody (ab140039) at 1 µg/mL

Lane 2:

Western blot - Anti-Dectin-1 antibody (ab140039) at 2 µg/mL

All lanes:

Rat spleen tissue lysate at 15 µg

Predicted band size: 28 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CLEC7A aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q9BXN2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "IHC-P suitable for Human samples only", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "WB for rat samples only.", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed : 11567029, PubMed : 12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B : upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed : 17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).

See full target information CLEC7A

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Publications (23)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:462 PubMed40270030

2025

TNF-α/NF-κB mediated upregulation of Dectin-1 in hyperglycemic obesity: implications for metabolic inflammation and diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Ashraf Al Madhoun,Dania Haddad,Shihab Kochumon,Reeby Thomas,Lavina Miranda,Preethi George,Nermeen Abu-Khalaf,Fahd Al-Mulla,Rasheed Ahmad

Frontiers in immunology 15:1361351 PubMed38846954

2024

CLEC7A regulates M2 macrophages to suppress the immune microenvironment and implies poorer prognosis of glioma.

Applications

Unspecified application

Species

Unspecified reactive species

Jinchao Wang,Xiaoru Li,Kai Wang,Kaiji Li,Yalong Gao,Jianye Xu,Ruilong Peng,Xu Zhang,Shu Zhang,Yuan Zhou,Shangchen Xu,Jianning Zhang

International journal of nanomedicine 18:7267-7285 PubMed38090362

2023

Drug Repositioning of Metformin Encapsulated in PLGA Combined with Photothermal Therapy Ameliorates Rheumatoid Arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Dae Kyu Kim,Jun Young Park,Youn Joo Kang,Dongwoo Khang

British journal of cancer 129:721-732 PubMed37422529

2023

C-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Liu,Kunpeng Lv,Jieti Wang,Chao Lin,Hao Liu,Heng Zhang,He Li,Yun Gu,Ruochen Li,Hongyong He,Jiejie Xu

Cellular and molecular life sciences : CMLS 80:184 PubMed37340199

2023

Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.

Applications

Unspecified application

Species

Unspecified reactive species

Shiju Ye,He Huang,Yun Xiao,Xue Han,Fengjie Shi,Wu Luo,Jiawen Chen,Yang Ye,Xia Zhao,Weijian Huang,Yi Wang,Dongwu Lai,Guang Liang,Guosheng Fu

Nature communications 14:1493 PubMed36932082

2023

Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.

Applications

Unspecified application

Species

Unspecified reactive species

Ce Tang,Haiyang Sun,Motohiko Kadoki,Wei Han,Xiaoqi Ye,Yulia Makusheva,Jianping Deng,Bingbing Feng,Ding Qiu,Ying Tan,Xinying Wang,Zehao Guo,Chanyan Huang,Sui Peng,Minhu Chen,Yoshiyuki Adachi,Naohito Ohno,Sergio Trombetta,Yoichiro Iwakura

Journal of immunology research 2022:3002304 PubMed36619719

2022

The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Dandan Zhang,Yue Jia,Xingzong Sun,Haoran Li,Min Yin,Hongliang Li,Lili Dai,Li Han,Lei Wang,Menghan Qian,Jing Du,Keming Zhu,Hongkun Bao

BMC gastroenterology 22:469 PubMed36401221

2022

Triclosan exposure induced disturbance of gut microbiota and exaggerated experimental colitis in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Liu,Yang Tao,Wang Haikun,Yang Lanfang,Lu Jingyi,Yao Ping

Journal of inflammation research 15:5917-5933 PubMed36274828

2022

Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiquan Ding,Zhenzhong Zhong,Jun Wang,Run Zhang,Jinlian Shao,Yulong Li,Guiwei Wu,Huiru Tu,Wen Yuan,Haitao Sun,Qinghua Wang

Cells 11: PubMed36139454

2022

Dectin-1 as a Potential Inflammatory Biomarker for Metabolic Inflammation in Adipose Tissue of Individuals with Obesity.

Applications

Unspecified application

Species

Unspecified reactive species

Ashraf Al Madhoun,Shihab Kochumon,Fatema Al-Rashed,Sardar Sindhu,Reeby Thomas,Lavina Miranda,Fahd Al-Mulla,Rasheed Ahmad

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Dectin-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dectin-1 antibody (AB140039)

Western blot - Anti-Dectin-1 antibody (AB140039)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Product protocols

Target data

Publications (23)

Product promise