Anti-DECTIN 2 antibody [IMG3D1]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DECTIN-2 also known as C-type lectin domain family 6 member A (CLEC6A) is a cell surface receptor that belongs to the C-type lectin family. It plays a significant role in the immune system by recognizing and binding to polysaccharides found on the surface of fungi such as alpha-mannans. DECTIN-2 is a type II transmembrane protein with an approximate molecular mass of 28 kDa. It is expressed mostly in dendritic cells and macrophages where it helps initiate immune responses against fungal pathogens.

Biological function summary

DECTIN-2 is a part of the innate immune system functioning through its association with the Fc receptor gamma chain to form a signaling complex. This interaction allows DECTIN-2 to transmit signals that lead to the activation of the NF-kB pathway which in turn stimulates the production of pro-inflammatory cytokines. The role of DECTIN-2 extends to influencing adaptive immunity as it helps in the maturation of dendritic cells and the proliferation of antigen-specific T cells.

Pathways

The DECTIN-2-mediated signaling integrates into the broader pattern recognition receptor pathways notably the C-type lectin receptor signaling pathway and the complement cascade. DECTIN-2 interacts closely with other proteins like DECTIN-1 another C-type lectin and complement protein C3 which together coordinate a more comprehensive immune response. These interactions enhance pathogen recognition and clearance emphasizing DECTIN-2's important position within the immune surveillance system.

Associated diseases and disorders

DECTIN-2 is particularly relevant in conditions such as fungal infections and autoimmune diseases. In fungal infections DECTIN-2 together with DECTIN-1 enhances the body's ability to detect and respond to pathogenic fungi reducing infection severity. Additionally abnormal DECTIN-2 signaling or expression may contribute to autoimmune disorders such as rheumatoid arthritis where overactive immune responses cause tissue damage. Understanding DECTIN-2's role could provide insight into potential therapeutic targets for managing these diseases.