Mouse Monoclonal DEFB-4 antibody. Suitable for ELISA, WB, IHC-P, RIA and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human DEFB104A aa 1 to C-terminus.
pH: 7.4
Constituents: 0.79% Tris HCl
| ELISA | WB | IHC-P | RIA | |
|---|---|---|---|---|
| Human | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
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Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
DEFB104, DEFB4, DEFB104B, DEFB104A, Beta-defensin 104, Beta-defensin 4, BD-4, DEFB-4, hBD-4
Mouse Monoclonal DEFB-4 antibody. Suitable for ELISA, WB, IHC-P, RIA and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human DEFB104A aa 1 to C-terminus.
pH: 7.4
Constituents: 0.79% Tris HCl
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DEFB-4 also known as beta-defensin 4 or human beta-defensin 2 (hBD-2) is a small antimicrobial peptide with a mass of about 4.5 kDa. This peptide belongs to the defensin family which plays a role in the immune response. DEFB-4 is expressed in epithelial cells including those in the skin respiratory tract and urogenital tract. It is induced by microbial presence and inflammatory cytokines such as IL-1 and TNF-alpha.
This peptide exhibits antimicrobial activity against bacteria fungi and viruses. DEFB-4 disrupts microbial membranes leading to microbe death. It does not form part of a larger protein complex but it plays an important role in immune defense by recruiting and activating immune cells. It also exhibits chemotactic properties suggesting an involvement in modulating immune responses and interactions with other innate immune system components.
DEFB-4 is involved in the innate immune pathway that mediates early responses to infections. Its interaction with the Toll-like receptor (TLR) pathways further enhances cytokine production. DEFB-4 acts alongside other beta-defensins like DEFB-1 contributing to a broader antimicrobial defensive network. Activation of these pathways results in coordinated immune responses that are critical during the early stages of microbial invasion.
The dysregulation of DEFB-4 expression associates with conditions such as psoriasis and cystic fibrosis. In psoriasis increased expression of DEFB-4 correlates with persistent inflammation and immune activity in the skin. In cystic fibrosis impaired DEFB-4 function can lead to an increased risk of chronic lung infections. The protein's relationship to IL-1 and TNF-alpha plays a role in these inflammatory conditions making DEFB-4 a target of interest for therapeutic research.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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