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AB14419

Anti-DEFB-4 antibody [L13-10-D1]

5

(1 Review)

|

(5 Publications)

Mouse Monoclonal DEFB-4 antibody. Suitable for ELISA, WB, IHC-P, RIA and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human DEFB104A aa 1 to C-terminus.

View Alternative Names

DEFB104, DEFB4, DEFB104B, DEFB104A, Beta-defensin 104, Beta-defensin 4, BD-4, DEFB-4, hBD-4

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

L13-10-D1

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, ELISA, IHC-P, RIA

applications

Immunogen

Synthetic Peptide within Human DEFB104A aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8WTQ1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: 0.79% Tris HCl
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DEFB-4 also known as beta-defensin 4 or human beta-defensin 2 (hBD-2) is a small antimicrobial peptide with a mass of about 4.5 kDa. This peptide belongs to the defensin family which plays a role in the immune response. DEFB-4 is expressed in epithelial cells including those in the skin respiratory tract and urogenital tract. It is induced by microbial presence and inflammatory cytokines such as IL-1 and TNF-alpha.
Biological function summary

This peptide exhibits antimicrobial activity against bacteria fungi and viruses. DEFB-4 disrupts microbial membranes leading to microbe death. It does not form part of a larger protein complex but it plays an important role in immune defense by recruiting and activating immune cells. It also exhibits chemotactic properties suggesting an involvement in modulating immune responses and interactions with other innate immune system components.

Pathways

DEFB-4 is involved in the innate immune pathway that mediates early responses to infections. Its interaction with the Toll-like receptor (TLR) pathways further enhances cytokine production. DEFB-4 acts alongside other beta-defensins like DEFB-1 contributing to a broader antimicrobial defensive network. Activation of these pathways results in coordinated immune responses that are critical during the early stages of microbial invasion.

The dysregulation of DEFB-4 expression associates with conditions such as psoriasis and cystic fibrosis. In psoriasis increased expression of DEFB-4 correlates with persistent inflammation and immune activity in the skin. In cystic fibrosis impaired DEFB-4 function can lead to an increased risk of chronic lung infections. The protein's relationship to IL-1 and TNF-alpha plays a role in these inflammatory conditions making DEFB-4 a target of interest for therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
See full target information DEFB104A
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Medicina (Kaunas, Lithuania) 59: PubMed36837507

2023

Morphopathogenesis of Adult Acquired Cholesteatoma.

Applications

Unspecified application

Species

Unspecified reactive species

Kristaps Dambergs,Gunta Sumeraga,Māra Pilmane

Diagnostics (Basel, Switzerland) 11: PubMed33673194

2021

Morphofunctional Characterization of Different Tissue Factors in Congenital Diaphragmatic Hernia Affected Tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Ricards Kaulins,Laura Ramona Rozite,Mara Pilmane,Aigars Petersons

Medicina (Kaunas, Lithuania) 55: PubMed31426487

2019

An Insight into COPD Morphopathogenesis: Chronic Inflammation, Remodeling, and Antimicrobial Defense.

Applications

Unspecified application

Species

Unspecified reactive species

Zane Vitenberga,Māra Pilmane,Aurika Babjoniševa

Archives of dermatology 148:182-6 PubMed22004878

2011

Hidradenitis suppurativa: the role of deficient cutaneous innate immunity.

Applications

ICC/IF

Species

Human

Brigitte Dréno,Amir Khammari,Anabelle Brocard,Dominique Moyse,Eric Blouin,Gerard Guillet,Fabienne Léonard,Anne-Chantal Knol

Histochemistry and cell biology 134:59-73 PubMed20526610

2010

Roles of human beta-defensins in innate immune defense at the ocular surface: arming and alarming corneal and conjunctival epithelial cells.

Applications

IHC-P, IHC-P

Species

Human, Mouse

Fabian Garreis,Thomas Schlorf,Dieter Worlitzsch,Philipp Steven,Lars Bräuer,Kristin Jäger,Friedrich P Paulsen
View all publications
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Product promise

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