Anti-DELE antibody - N-terminal

Target data

Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency, mitochondrial stress or mitochondrial DNA breaks (PubMed : 32132706, PubMed : 32132707, PubMed : 35388015, PubMed : 37327776, PubMed : 37550454, PubMed : 37832546, PubMed : 38340717). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed : 35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed : 20563667).. DAP3-binding cell death enhancer 1. Protein kinase activator that activates the ISR in response to iron deficiency : iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR.. DAP3-binding cell death enhancer 1 short form. Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed : 32132706, PubMed : 32132707, PubMed : 37327776, PubMed : 37550454, PubMed : 37832546, PubMed : 38340717). It thereby activates the integrated stress response (ISR) : EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed : 32132706, PubMed : 32132707, PubMed : 37327776, PubMed : 37550454, PubMed : 37832546). Also acts as an activator of PRKN-independent mitophagy : activates the protein kinase activity of EIF2AK1/HRI in response to mitochondrial damage, promoting eIF-2-alpha (EIF2S1) phosphorylation, leading to mitochondrial localization of EIF2S1 followed by induction of mitophagy (PubMed : 38340717).