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AB126355

Anti-Delphilin antibody

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(1 Publication)

Rabbit Polyclonal Delphilin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Delphilin aa 800-950.

View Alternative Names

Delphilin, GRID2IP

1 Images
Western blot - Anti-Delphilin antibody (AB126355)
  • WB

Supplier Data

Western blot - Anti-Delphilin antibody (AB126355)

All lanes:

Western blot - Anti-Delphilin antibody (ab126355) at 0.4 µg/mL

All lanes:

U-251 MG (formerly U-373 MG) (Human brain glioma cell line) whole cell lysate

Predicted band size: 132 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human Delphilin aa 800-950. The exact immunogen used to generate this antibody is proprietary information.

A4D2P6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Delphilin also known as Atrophin-interacting protein 1 (DIP1) is a scaffold protein that plays a role in the organization of postsynaptic density. It is a protein of approximately 200 kDa. Delphilin is prominently expressed in the brain especially in the cerebellum where it localizes to the postsynaptic side of parallel fiber-Purkinje cell synapses. This location suggests its important role in synaptic signaling and neural communication.
Biological function summary

Delphilin contributes to the formation and maintenance of synaptic structures. It interacts with various synaptic proteins facilitating the assembly of protein complexes needed for synaptic function. One of its main interactions is with glutamate receptors specifically the delta-2 glutamate receptor. This interaction is essential for the proper clustering of these receptors at synapses which influences synaptic strength and plasticity. Delphilin also plays part in scaffolding networks that stabilize synaptic architecture.

Pathways

Delphilin is involved in the glutamatergic synapse pathway. This pathway is important for excitatory neurotransmission in the central nervous system. Delphilin interacts closely with proteins such as PSD-95 an important player in synapse assembly and organization. It is also part of Calcium/calmodulin-dependent protein kinase II (CaMKII) signaling which impacts synaptic plasticity and memory processes.

Delphilin may be linked to neurodegenerative diseases such as spinocerebellar ataxia. Disruptions in Delphilin's interactions can impair synaptic function contributing to progressive motor dysfunction found in these conditions. Additionally alterations in Delphilin expression or function have been investigated in relation to autism spectrum disorders potentially through its relationship with proteins like NMDA receptors implicated in synaptic connectivity anomalies seen in autism.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
See full target information Delphilin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112722 PubMed40546969

2025

Distinct functions of PAXX and MRI during chromosomal end joining.

Applications

Unspecified application

Species

Unspecified reactive species

Metztli Cisneros-Aguirre,Felicia Wednesday Lopezcolorado,Xiaoli Ping,Ruby Chen,Jeremy M Stark
View all publications
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Product promise

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