Anti-delta II tubulin antibody - Loading Control

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Delta II tubulin participates in the assembly and dynamics of microtubule structures fundamental for mitosis and meiosis. It is often part of the tubulin complex where it assists in the stabilization of spindle microtubules during cell division. This function is critical in nerve cells where the maintenance of structural integrity and transport accuracy is essential. By achieving this delta II tubulin supports various cellular activities including the movement of organelles and signaling molecules along the axons and dendrites.

Pathways

Delta II tubulin integrates into the intricate microtubule pathways governing cellular division and transport. A significant pathway involving this protein includes the mitotic spindle checkpoint important for chromosome segregation and cell cycle control. It interacts with other tubulin isotypes and mitotic spindle-associated proteins helping ensure accurate chromosomal alignment and segregation. Delta II tubulin also interfaces with kinesin and dynein motor proteins facilitating intracellular transport.