Anti-Delta Opioid Receptor (phospho S363) antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Delta Opioid Receptor also known as DOR is a G protein-coupled receptor involved in the modulation of pain mood and neuroprotection. It is a transmembrane protein with a mass around 40 kDa. The receptor is often expressed in the central nervous system particularly in areas such as the brain and spinal cord. Due to its role in analgesic pathways the receptor's function is of great interest for pain management therapies. Present in various tissues the presence of delta opioid receptors can influence different physiological processes.

Biological function summary

Delta opioid receptors participate in the modulation of neurotransmitter release neuronal excitability and neurogenesis. These receptors form part of a complex that includes other opioid receptors such as mu and kappa receptors interacting to fine-tune the body's response to pain and stress. Activation of delta opioid receptors results in analgesic effects making them potential targets for therapeutic interventions in pain management. Their expression in peripheral tissues also suggests roles in immune and inflammatory responses.

Pathways

Delta opioid receptors fit into the opioid receptor signaling cascades that influence pain perception and reward mechanisms. The major pathways include the adenylate cyclase inhibition pathway which reduces the production of cAMP and the MAPK cascade promoting cell survival and differentiation. These receptors commonly interact with G proteins such as Gi/o proteins to mediate cellular responses. Delta 5029 and delta 193 are segments of research focusing on specific pathways where delta 193 relates to receptor trafficking and delta 5029 involves receptor desensitization mechanisms.

Delta opioid receptors are linked to conditions like chronic pain and depression. Alterations in delta opioid receptor expression or function contribute to these disorders suggesting their involvement in pathological states. Through their involvement in opioid signaling they connect to disorders characterized by altered brain chemistry such as depression. Proteins interacting with delta receptors in these contexts include other opioid receptors which share overlapping roles in emotional regulation and pain perception. Antagonists or agonists like anti-delta antibodies are researched for potential therapeutic applications in these diseases.