Mouse Monoclonal DeltaD antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC - Wmt, IHC-Fr and reacts with Zebrafish samples. Cited in 12 publications. Immunogen corresponding to Native Full Length Protein corresponding to Zebrafish dld.
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
| Flow Cyt | ELISA | WB | ICC/IF | IHC - Wmt | IHC-Fr | |
|---|---|---|---|---|---|---|
| Zebrafish | Expected | Expected | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info - | Notes ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Zebrafish | Dilution info Use at an assay dependent concentration. | Notes - |
Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
aei, dld, Delta-like protein D, DeltaD, After eight protein
Mouse Monoclonal DeltaD antibody. Suitable for Flow Cyt, ELISA, WB, ICC/IF, IHC - Wmt, IHC-Fr and reacts with Zebrafish samples. Cited in 12 publications. Immunogen corresponding to Native Full Length Protein corresponding to Zebrafish dld.
Preservative: 0.02% Sodium azide
Constituents: 99.98% PBS
This antibody recognises the extracellular domain of zebrafish DeltaD. This antibody does not detect DeltaC; but it cross-reacts weakly with DeltaA.
DeltaD also known as Notch ligand Delta-like 3 is a member of the Delta/Notch family. It has a molecular mass of approximately 60 kDa. Expression of DeltaD occurs mainly in human embryonic tissues though it is also present in some adult tissues including brain and muscle. The Notch signaling pathway where DeltaD functions as a ligand is essential for communication between adjacent cells via binding with Notch receptors.
Proteins from the Delta/Notch family influence numerous developmental processes. DeltaD participates in the regulation of cell fate determination and differentiation during embryonic development. It works within the Notch signaling pathway where it forms a complex with Notch receptors and other ligands to control the transcription of target genes. The modulation of Notch signaling by DeltaD is important for proper tissue patterning and morphogenesis.
Many cellular activities rely on DeltaD's interaction with the Notch signaling pathway. This pathway influences critical processes such as angiogenesis and neurogenesis. Within these framework DeltaD interacts with several Notch receptors such as Notch1 and Notch2 to regulate gene expression. The interplay between DeltaD and these receptors ensures the correct execution of developmental programs and cellular differentiation.
Dysregulation of DeltaD expression associates with congenital conditions such as spondylocostal dysostosis and neural tube defects. Anomalies in the Notch signaling pathway where DeltaD acts can disrupt normal development resulting in such pathologies. Notch1 and other family members are involved in the pathophysiology of these disorders emphasizing DeltaD's role in maintaining proper developmental signaling and tissue function.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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