Anti-DENN antibody [EPR4919]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The DENN domain-containing proteins also referred to as DENN serve as specific guanine nucleotide exchange factors (GEFs) that activate Rab GTPases important for vesicular trafficking. These proteins generally weigh between 110 to 150 kDa. DENN proteins predominantly are found within cellular membranes including endosomes. This positioning is consistent with their involvement in vesicle trafficking and membrane dynamics.

Biological function summary

DENN domain proteins facilitate critical processes such as endocytic recycling autophagy and transport processes within cells. These proteins belong to a complex containing multiple subunits that coordinate the activation of Rab GTPases. Through these activities DENN proteins ensure proper membrane trafficking dynamics and cellular organization integral to maintaining cell function.

Pathways

DENN proteins participate in cellular pathways like endocytic recycling and autophagy. In the endocytic pathway DENN proteins regulate Rab GTPases such as Rab5 and Rab7 controlling vesicle formation and movement. They also play a part in mTOR signaling influencing cell growth and autophagy regulation. By interacting with these key pathways DENN domain proteins help to integrate signals and coordinate cellular responses to environmental changes.

Associated diseases and disorders

Alterations in DENN proteins often relate to neurodegenerative disorders and cancer. Mutations in the DENN domain have links to conditions such as Parkinson’s disease where Rab GTPases affected are implicated in neuronal function and survival. In cancer dysregulation of DENN protein function can influence cellular proliferation and apoptosis affecting tumor development. DENN proteins through their interactions and related pathways represent significant factors in understanding and potentially addressing these conditions.