Rabbit Polyclonal Deoxynevalenol antibody. Suitable for ELISA and reacts with Chemical samples. Immunogen corresponding to Chemical / Small Molecule corresponding to Deoxynevalenol.
Constituents: Whole serum
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Species Chemical | Dilution info Use at an assay dependent concentration. | Notes - |
DON
Rabbit Polyclonal Deoxynevalenol antibody. Suitable for ELISA and reacts with Chemical samples. Immunogen corresponding to Chemical / Small Molecule corresponding to Deoxynevalenol.
Constituents: Whole serum
Reacts specifically with Deoxynivalenol mycotoxin.
Deoxynevalenol also known as vomitoxin is a type B trichothecene mycotoxin with a molecular mass of 296.3 g/mol. Agricultural products infected by Fusarium species express deoxynevalenol. Vomitoxin formation occurs primarily in grains like wheat barley and maize especially in conditions with high moisture and temperature. This compound is not a protein but serves as a biological target due to its significant impact on crop safety and food security.
Deoxynevalenol disrupts protein synthesis by binding to ribosomal peptidyl transferase impeding peptide bond formation. It is not part of a protein complex but interacts with the eukaryotic translation machinery. This interaction triggers ribotoxic stress response which affects various cellular functions including cell growth and apoptosis. The presence of this mycotoxin in agricultural environments is a concern for both plant and animal health making it an important target for study.
Deoxynevalenol plays a role in the mitogen-activated protein kinase (MAPK) pathway. The activation of this pathway occurs due to ribosomal damage leading to the modulation of stress response genes. Deoxynevalenol indirectly affects the immune response linking it to pro-inflammatory cytokine production. Proteins like c-Jun N-terminal kinase (JNK) and p38 MAPK relate to deoxynevalenol in this context contributing to its effects at the cellular level.
Deoxynevalenol exposure has links to respiratory and gastrointestinal conditions. It acts as an immunosuppressive agent compounding the risk of infections and inflammatory diseases. The immune-modulating effects of deoxynevalenol are associated with proteins such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Understanding these associations can inform mitigation strategies in agriculture and improve public health responses.
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