Anti-Deoxynevalenol antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Deoxynevalenol disrupts protein synthesis by binding to ribosomal peptidyl transferase impeding peptide bond formation. It is not part of a protein complex but interacts with the eukaryotic translation machinery. This interaction triggers ribotoxic stress response which affects various cellular functions including cell growth and apoptosis. The presence of this mycotoxin in agricultural environments is a concern for both plant and animal health making it an important target for study.

Pathways

Deoxynevalenol plays a role in the mitogen-activated protein kinase (MAPK) pathway. The activation of this pathway occurs due to ribosomal damage leading to the modulation of stress response genes. Deoxynevalenol indirectly affects the immune response linking it to pro-inflammatory cytokine production. Proteins like c-Jun N-terminal kinase (JNK) and p38 MAPK relate to deoxynevalenol in this context contributing to its effects at the cellular level.