Rabbit Polyclonal DERL3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DERL3.
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- Frontiers in immunology 13:9064202022Integrated profiling of endoplasmic reticulum stress-related DERL3 in the prognostic and immune features of lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLanlan Lin,Guofu Lin,Hai Lin,Luyang Chen,Xiaohui Chen,Qinhui Lin,Yuan Xu,Yiming ZengPubMed 36275646
- Nature communications 5:36082014A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.Applications:WBReactive species:Unspecified reactive speciesPaula Lopez-Serra,Miguel Marcilla,Alberto Villanueva,Antonio Ramos-Fernandez,Anna Palau,Lucía Leal,Jessica E Wahi,Fernando Setien-Baranda,Karolina Szczesna,Catia Moutinho,Anna Martinez-Cardus,Holger Heyn,Juan Sandoval,Sara Puertas,August Vidal,Xavier Sanjuan,Eva Martinez-Balibrea,Francesc Viñals,Jose C Perales,Jesper B Bramsem,Torben F Ørntoft,Claus L Andersen,Josep Tabernero,Ultan McDermott,Matthew B Boxer,Matthew G Vander Heiden,Juan Pablo Albar,Manel EstellerPubMed 24699711
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human DERL3. The exact immunogen used to generate this antibody is proprietary information. Database link Q96Q80
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
Target data
Function
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).
Alternative names
C22orf14, DER3, LLN2, DERL3, Derlin-3, Degradation in endoplasmic reticulum protein 3, Der1-like protein 3, DERtrin-3
Recommended products
Rabbit Polyclonal DERL3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DERL3.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human DERL3. The exact immunogen used to generate this antibody is proprietary information. Database link Q96Q80
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The DERL3 protein also known as Derlin-3 plays an important role in the endoplasmic reticulum-associated degradation (ERAD) pathway. It acts as a retrotranslocation channel for misfolded glycoproteins that need degradation. The protein weighs approximately 27 kDa and is expressed mainly in tissues with high protein synthesis demands such as the heart and skeletal muscle.
- Biological function summary
DERL3 functions in the recognition and translocation of misfolded proteins to the cytosol where they are degraded by the proteasome. It is part of a larger complex involving other ERAD components that help maintain protein quality control within the endoplasmic reticulum. This function ensures cellular homeostasis by preventing the accumulation of improperly folded proteins.
- Pathways
DERL3 plays a vital role in the unfolded protein response (UPR) and proteostasis networks. These pathways ensure cells respond to an accumulation of misfolded proteins properly. DERL3 works alongside proteins like HRD1 and SEL1L in facilitating the ERAD pathway emphasizing its contribution to cellular stress response mechanisms.
- Associated diseases and disorders
DERL3 has been implicated in cancer and neurodegenerative diseases. Its dysfunction can lead to the buildup of misfolded proteins contributing to disease progression. One key connection is with the protein p97/VCP which interacts with DERL3 in the clearance of misfolded proteins highlighting its importance in maintaining proteostasis in various pathological conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DERL3 antibody (ab78233)
Immunohistochemistry analysis of formalin-fixed, paraffin embedded Human pancreas tissue using ab78233 at 20µg/ml.
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