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AB78233

Anti-DERL3 antibody

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(2 Publications)

Rabbit Polyclonal DERL3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DERL3.

View Alternative Names

C22orf14, DER3, LLN2, DERL3, Derlin-3, Degradation in endoplasmic reticulum protein 3, Der1-like protein 3, DERtrin-3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DERL3 antibody (AB78233)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DERL3 antibody (AB78233)

Immunohistochemistry analysis of formalin-fixed, paraffin embedded Human pancreas tissue using ab78233 at 20µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human DERL3. The exact immunogen used to generate this antibody is proprietary information.

Q96Q80

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Primary Antibodies

AB176732

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DERL1/Derlin-1 antibody (AB176732)

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Primary Antibodies

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Secondary Antibodies

AB99817

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DERL3 protein also known as Derlin-3 plays an important role in the endoplasmic reticulum-associated degradation (ERAD) pathway. It acts as a retrotranslocation channel for misfolded glycoproteins that need degradation. The protein weighs approximately 27 kDa and is expressed mainly in tissues with high protein synthesis demands such as the heart and skeletal muscle.
Biological function summary

DERL3 functions in the recognition and translocation of misfolded proteins to the cytosol where they are degraded by the proteasome. It is part of a larger complex involving other ERAD components that help maintain protein quality control within the endoplasmic reticulum. This function ensures cellular homeostasis by preventing the accumulation of improperly folded proteins.

Pathways

DERL3 plays a vital role in the unfolded protein response (UPR) and proteostasis networks. These pathways ensure cells respond to an accumulation of misfolded proteins properly. DERL3 works alongside proteins like HRD1 and SEL1L in facilitating the ERAD pathway emphasizing its contribution to cellular stress response mechanisms.

DERL3 has been implicated in cancer and neurodegenerative diseases. Its dysfunction can lead to the buildup of misfolded proteins contributing to disease progression. One key connection is with the protein p97/VCP which interacts with DERL3 in the clearance of misfolded proteins highlighting its importance in maintaining proteostasis in various pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed : 16449189, PubMed : 22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed : 26565908).
See full target information DERL3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:906420 PubMed36275646

2022

Integrated profiling of endoplasmic reticulum stress-related DERL3 in the prognostic and immune features of lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lanlan Lin,Guofu Lin,Hai Lin,Luyang Chen,Xiaohui Chen,Qinhui Lin,Yuan Xu,Yiming Zeng

Nature communications 5:3608 PubMed24699711

2014

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Applications

WB

Species

Unspecified reactive species

Paula Lopez-Serra,Miguel Marcilla,Alberto Villanueva,Antonio Ramos-Fernandez,Anna Palau,Lucía Leal,Jessica E Wahi,Fernando Setien-Baranda,Karolina Szczesna,Catia Moutinho,Anna Martinez-Cardus,Holger Heyn,Juan Sandoval,Sara Puertas,August Vidal,Xavier Sanjuan,Eva Martinez-Balibrea,Francesc Viñals,Jose C Perales,Jesper B Bramsem,Torben F Ørntoft,Claus L Andersen,Josep Tabernero,Ultan McDermott,Matthew B Boxer,Matthew G Vander Heiden,Juan Pablo Albar,Manel Esteller
View all publications
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Product promise

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