Rabbit Polyclonal Desmuslin/SYN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Synemin aa 1450-1550.
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- International journal of molecular sciences 21:2020c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSara Sofia Deville et. al.PubMed 33019757
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Synemin aa 1450-1550. The exact immunogen used to generate this antibody is proprietary information. Database link O15061
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/2500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
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Target data
Function
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Alternative names
DMN, KIAA0353, SYN, DMN, SYN, KIAA0353, SYNM, Synemin, Desmuslin
Recommended products
Rabbit Polyclonal Desmuslin/SYN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Synemin aa 1450-1550.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Synemin aa 1450-1550. The exact immunogen used to generate this antibody is proprietary information. Database link O15061
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Desmuslin also known as SYN or Synemin is an intermediate filament protein with a mass of approximately 180 kDa. It is prominently expressed in muscle tissues including skeletal cardiac and smooth muscles. Desmuslin integrates into the cytoskeleton providing essential structural support and maintaining cellular integrity. Its expression is not restricted to muscle tissues; desmuslin also appears in certain non-muscle cells indicating its diverse functional roles.
- Biological function summary
The protein desmuslin plays an important role in maintaining cellular architecture and mechanical stability. It associates closely with the cytoskeletal network and participates in the actin-binding protein complex. Desmuslin interacts with various cytoskeletal components anchoring them to the sarcolemma and linking the extracellular matrix to the cytoskeleton. This interaction supports cellular resilience against mechanical stress and contributes to tissue homeostasis.
- Pathways
The protein desmuslin integrates into cell adhesion and signaling pathways. It links mechanically to pathways involving integrins which facilitate cell adhesion and communication with the extracellular matrix. Through these pathways desmuslin associates with proteins like plectin and dystrophin which also contribute to structural integrity. This interaction aids in the transmission of mechanical signals integrating external stimuli with intracellular responses and supports proper muscle function.
- Associated diseases and disorders
The protein desmuslin associates with conditions such as muscular dystrophy and cardiomyopathies. Mutations or dysregulation of desmuslin can disrupt muscle integrity leading to progressive muscle weakness and degeneration. Desmuslin interacts with the dystrophin-glycoprotein complex which when altered can also contribute to the development of muscular dystrophy. Additionally desmuslin plays a role in maintaining cardiac muscle function and its dysfunction relates to certain cardiomyopathies posing significant implications for cardiac health.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (ab204369)
Immunohistochemical analysis of formalin-fixed paraffin-embedded human skeletal muscle tissue labeling Desmuslin/SYN with ab204369 at 1/1000 dilution.
Strong cytoplasmic positivity in myocytes.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (ab204369)
Immunohistochemical analysis of formalin-fixed paraffin-embedded human prostate tissue labeling Desmuslin/SYN with ab204369 at 1/1000 dilution.
Strong cytoplasmic positivity in small muscle cells.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (ab204369)
Immunohistochemical analysis of formalin-fixed paraffin-embedded human liver tissue labeling Desmuslin/SYN with ab204369 at 1/1000 dilution.
No cytoplasmic positivity in hepatocytes.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (ab204369)
Immunohistochemical analysis of formalin-fixed paraffin-embedded human heart muscle tissue labeling Desmuslin/SYN with ab204369 at 1/1000 dilution.
Strong cytoplasmic positivity in cardiomyocytes.
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