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AB214316

Anti-Desmuslin/SYN antibody

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(2 Publications)

Rabbit Polyclonal Desmuslin/SYN antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SYNM aa 500-550 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

DMN, KIAA0353, SYN, SYNM, Synemin, Desmuslin

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (AB214316)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (AB214316)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat heart tissue labeling Desmuslin/SYN with ab214316 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (AB214316)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmuslin/SYN antibody (AB214316)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Desmuslin/SYN with ab214316 at 1/4200 dilution, followed by FITC conjugated secondary antibody.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SYNM aa 500-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

O15061

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Desmuslin also known as SYN or Synemin is an intermediate filament protein with a mass of approximately 180 kDa. It is prominently expressed in muscle tissues including skeletal cardiac and smooth muscles. Desmuslin integrates into the cytoskeleton providing essential structural support and maintaining cellular integrity. Its expression is not restricted to muscle tissues; desmuslin also appears in certain non-muscle cells indicating its diverse functional roles.
Biological function summary

The protein desmuslin plays an important role in maintaining cellular architecture and mechanical stability. It associates closely with the cytoskeletal network and participates in the actin-binding protein complex. Desmuslin interacts with various cytoskeletal components anchoring them to the sarcolemma and linking the extracellular matrix to the cytoskeleton. This interaction supports cellular resilience against mechanical stress and contributes to tissue homeostasis.

Pathways

The protein desmuslin integrates into cell adhesion and signaling pathways. It links mechanically to pathways involving integrins which facilitate cell adhesion and communication with the extracellular matrix. Through these pathways desmuslin associates with proteins like plectin and dystrophin which also contribute to structural integrity. This interaction aids in the transmission of mechanical signals integrating external stimuli with intracellular responses and supports proper muscle function.

The protein desmuslin associates with conditions such as muscular dystrophy and cardiomyopathies. Mutations or dysregulation of desmuslin can disrupt muscle integrity leading to progressive muscle weakness and degeneration. Desmuslin interacts with the dystrophin-glycoprotein complex which when altered can also contribute to the development of muscular dystrophy. Additionally desmuslin plays a role in maintaining cardiac muscle function and its dysfunction relates to certain cardiomyopathies posing significant implications for cardiac health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
See full target information SYNM
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Annals of medicine and surgery (2012) 86:2644-2650 PubMed38694326

2024

S100A6 could not promote the differentiation of Calu-6 lung cancer cell line.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Li,Ting Wang,Dan Dang

Scientific reports 11:5496 PubMed33750814

2021

Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Miguel Angel Merlos Rodrigo,Hana Michalkova,Vladislav Strmiska,Berta Casar,Piero Crespo,Vivian de Los Rios,J Ignacio Casal,Yazan Haddad,Roman Guran,Tomas Eckschlager,Petra Pokorna,Zbynek Heger,Vojtech Adam
View all publications
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Product promise

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