AB215191

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal

Name: Anti-DFNA5/GSDME antibody - N-terminal [EPR19859] (ab215191) | Abcam
Brand: Abcam Limited
SKU: AB215191
Price: 285 USD
Availability: InStock
Rating: 5 (4 reviews)

20ul selling size
RabMAb
Recombinant
KO Validated
What is this?

(4 Reviews)

(285 Publications)

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) is a rabbit monoclonal antibody detecting DFNA5/GSDME in Western Blot, Flow Cytometry (Intra), IP. Suitable for Human, Mouse, Rat.

- Clone EPR19859 is the most cited clone to DFNA5/GSDME
- KO validated for confirmed specificity
- Biophysical QC for unrivalled batch-batch consistency
- Over 150 publications

View Alternative Names

DFNA5, ICERE1, GSDME, Gasdermin-E, Inversely correlated with estrogen receptor expression 1, Non-syndromic hearing impairment protein 5, ICERE-1

12 Images

Supplier Data

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Exposure times :

Lane 1 : 15s

Lane 2 : 3 min

The band around 35kDa is GSDME-NT which might be cleaved by activated caspase‐3 (PMID : 33589596, PMID : 31347748,PMID : 35623158).

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 1/1000 dilution

Lane 1:

SH-SY5Y (Human neuroblastoma epithelial cell) whole cell lysates at 20 µg

Lane 2:

SW480 (Human colorectal adenocarcinoma epithelial cell) whole cell lysates at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 54 kDa

Observed band size: 55 kDa

false

Flow Cytometry (Intracellular) - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Intracellular flow cytometric analysis of 4% paraformaldehyde-fixed, 90% methanol permeabilized SH-SY5Y (human neuroblastoma cell line from bone marrow) cell line labeling DFNA5/GSDME with ab215191 at 1/60 dilution (red) compared with a Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730) (black) and an unlabeled control (cells without incubation with primary antibody and secondary antibody) (blue). Goat Anti-Rabbit IgG H&L (Alexa Fluor^® 488) (ab150077) at 1/2000 dilution was used as the secondary antibody.

Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Intracellular flow cytometric analysis of 4% paraformaldehyde-fixed, 90% methanol permeabilized EMT6 (mouse mammary carcinoma cell line) cell line labeling DFNA5/GSDMEwith ab215191 at 1/600 dilution (red) compared with a Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730) (black) and an unlabeled control (cells without incubation with primary antibody and secondary antibody) (blue). Goat Anti-Rabbit IgG H&L (Alexa Fluor^®488) (ab150077) at 1/2000 dilution was used as the secondary antibody.

EMT6 cells were kindly provided by our collaborator Dr. Feng Shao, NIBS

Lab

Immunoprecipitation - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

ab215191 at 1/30 immunoprecipitating DFNA5/GSDME in EMT6 (mouse mammary carcinoma cell line) whole cell lysate.

Lane 1 (input) : EMT6 whole cell lysate (10μg)

Lane 2 (+) : ab215191 + EMT6 whole cell lysate

Lane 3 (-) : Rabbit monoclonal IgG (ab172730) instead of ab215191 in EMT6 whole cell lysate

For western blotting, ab215191 at 1/500. VeriBlot for IP Detection Reagent (HRP) (ab131366), was used for detection at 1/1,000 dilution

Blocking buffer and concentration : 5% NFDM/TBST.

Diluting buffer and concentration : 5% NFDM /TBST.

EMT6 cells were kindly provided by our collaborator Dr. Feng Shao, NIBS

All lanes:

Immunoprecipitation - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191)

Predicted band size: 54 kDa

false

Exposure time: 55s

Lab

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Different batches of ab215191 were tested on SH-SY5Y (Human neuroblastoma epithelial cell) lysate at 0.6 µg/ml. 15 µg of lysate was loaded in each lane. Bands observed at 55 kDa.

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191)

Predicted band size: 54 kDa

false

Lab

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Blocking and dilution buffer : 5% NFDM/TBST.

Exposure time : Lanes 1-3 : 10 seconds , Lanes 4-6 : 40 seconds.

Both ab215191 and ab221843 show negative result in MCF7, which is also consistent with the predicted expression pattern.

Lanes 1 and 4:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 1/1000 dilution

Lanes 2 and 5:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859-60] - C-terminal (<a href='/en-us/products/primary-antibodies/dfna5-gsdme-antibody-epr19859-60-c-terminal-ab221843'>ab221843</a>) at 1/1000 dilution

Lanes 1 - 3:

SH-SY5Y (Human neuroblastoma epithelial cell) whole cell lysate at 20 µg

Lanes 4 - 6:

MCF7 (Human breast adenocarcinoma epithelial cell) whole cell lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Predicted band size: 54 kDa

Observed band size: 55 kDa

false

Supplier Data

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Blocking/Dilution buffer : 5% NFDM/TBST.

The molecular weight observed is consistent with what has been described in the literature (PMID : 28459430).

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 1/1000 dilution

All lanes:

Human fetal brain lysate at 10 µg

Secondary

All lanes:

Western blot - VeriBlot for IP Detection Reagent (HRP) (<a href='/en-us/products/reagents/veriblot-for-ip-detection-reagent-hrp-ab131366'>ab131366</a>) at 1/100000 dilution

Predicted band size: 54 kDa

Observed band size: 55 kDa

true

Exposure time: 3min

Supplier Data

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Blocking/Dilution buffer : 5% NFDM/TBST.

The cell lysates were kindly provided by our collaborator, Dr. Feng Shao, NIBS.

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 1/5000 dilution

Lane 1:

SH-SY5Y (human neuroblastoma cell line from bone marrow) whole cell lysate at 10 µg

Lane 2:

DFNA5/GSDME knockout SH-SY5Y (human neuroblastoma cell line from bone marrow) whole cell lysate at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 54 kDa

Observed band size: 55 kDa

true

Exposure time: 15s

PubMed

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

https://www.sciencedirect.com/journal/biochemical-and-biophysical-research-communications

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 1/1000 dilution

Lane 1:

Wild Type SGC-7901 (human papillomavirus-related endocervical adenocarcinoma cell line) cell lysates

Lane 2:

DFNA5/GSDME Knockout SGC-7901 cell lysates

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab6721'>ab6721</a>) at 1/2000 dilution

Predicted band size: 54 kDa

false

Image from Wang Y et al., Biochem Biophys Res Commu. 2018;495(1):1418-1425. Fig 4(A).; 10.1016/j.bbrc.2017.11.156 with permission from Elsevier.

Supplier Data

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Blocking/Dilution buffer : 5% NFDM/TBST.

The molecular weight observed is consistent with what has been described in the literature (PMID : 28459430).

The EMT6 cell lysate was kindly provided by our collaborator Dr. Feng Shao, NIBS.

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 1/1000 dilution

Lane 1:

EMT6 (mouse mammary carcinoma cell line) whole cell lysate at 10 µg

Lane 2:

Mouse brain lysate at 10 µg

Lane 3:

Rat brain lysate at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 54 kDa

Observed band size: 55 kDa

true

Exposure time: 3min

Lab

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Blocking and diluting buffer : 5% NFDM/TBST

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 0.7 µg/mL

Lane 1:

Mouse brain tissue lysate at 20 µg

Lane 2:

Mouse kidney tissue lysate at 20 µg

Lane 3:

Mouse liver tissue lysate at 20 µg

Lane 4:

Mouse thymus tissue lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG) at 1/2000 dilution

Predicted band size: 54 kDa

Observed band size: 55 kDa

false

Exposure time: 3min

Supplier Data

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Blocking/Dilution buffer : 5% NFDM/TBST.

This antibody is specific to the N-terminus of DFNA5/GSDME.

The cell lysates were kindly provided by our collaborator, Dr. Feng Shao, NIBS.

All lanes:

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) at 1/10000 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) transfected with a control vector containing DDDDK tag, whole cell lysate at 20 µg

Lane 2:

HEK-293 (human epithelial cell line from embryonic kidney) transfected with DDDDK tagged DFNA5/GSDME (N-terminal) expression vector, whole cell lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Predicted band size: 54 kDa

Observed band size: 37 kDa

true

Exposure time: 1s

Carrier free

Anti-DFNA5/GSDME antibody [EPR19859] - BSA and Azide free
519 Alexa Fluor® 488

Alexa Fluor® 488 Anti-DFNA5/GSDME antibody [EPR19859]
578 PE

PE Anti-DFNA5/GSDME antibody [EPR19859]

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR19859

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IP, Flow Cyt (Intra), WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Our previous testing data indicates that this antibody detects no signal or very weak signal in mouse heart, spleen, lung, stomach, testicle, skin, pancreas, muscle and lymph node tissues. Final results may be affected by the expression level of the tested samples.

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Reactivity data

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Product details

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), IP and WB.

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) was first used in a scientific publication in 2017 and has been cited over 153 times in peer reviewed journals. It's performance in Western blot in mouse samples is trusted by the scientific community.

Abcam's high quality manufacturing and validation processes ensure Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.

The specificity of Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) has been confirmed by Western Blot testing in DFNA5/GSDME knockout SGC-7901 cells.

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) has 4 independent reviews from customers.

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (ab215191) specifically detects DFNA5/GSDME (UniProt ID: O60443; Molecular weight: 55kDa) and is sold in 100 µL and 1 mL selling sizes.

Conjugation-ready, carrier free format available for antibody clone EPR19859 - ab223877.

Antibody clone EPR19859 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor^® 488, PE (ab225519, ab225520).

Gasdermin E (GSDME) plays a significant role in immunology by modulating the immune response, particularly through its involvement in pyroptosis, a form of programmed cell death

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DFNA5 also known as GSDME (Gasdermin E) is a protein encoded by the GSDME gene. It has a molecular mass of approximately 59 kDa. The protein is expressed in various tissues including the cochlea in the inner ear and some epithelial tissues. Mechanically DFNA5/GSDME plays a role in inducing cell membrane pore formation leading to cell lysis. This activity relates to its involvement in processes like cell death specifically pyroptosis where the cell undergoes a form of programmed necrosis.

Biological function summary

DFNA5/GSDME serves as a pore-forming protein that facilitates pyroptotic cell death usually upon cleavage by caspase-3. This activity is important for innate immune response and the maintenance of cellular homeostasis. DFNA5/GSDME operates independently and does not form part of large protein complexes. The cleaved form inserts into the lipid bilayer of cell membranes contributing to the execution of cell death particularly under stress conditions or cellular insult.

Pathways

DFNA5/GSDME is involved in the pyroptosis and apoptosis pathways. It plays an essential role in the cellular response to inflammation and stress signals by interacting with caspase-3 a critical protease in the apoptosis pathway. The balance between apoptosis and pyroptosis decides cell fate with DFNA5/GSDME activation tipping towards pyroptotic cell death. The interconnection with other gasdermin family proteins such as GSDMD is notable as they share functional and structural similarities in promoting necrosis-like cell death processes.

Mutations in the DFNA5 gene relate to progressive hearing loss (nonsyndromic sensorineural deafness). Dysregulation of GSDME has also been implicated in cancer where altered expression promotes tumorigenesis or tumor suppression depending on the context. In hearing loss GSDME's interaction with pathways influencing apoptosis highlights its pathogenic role while in cancer connections to caspase-3 show a potential dichotomy in cell survival and cell death regulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Gasdermin-E. Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis (PubMed : 27281216, PubMed : 28459430, PubMed : 33852854, PubMed : 35594856, PubMed : 36607699). This form constitutes the precursor of the pore-forming protein : upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed : 28459430).. Gasdermin-E, N-terminal. Pore-forming protein produced by cleavage by CASP3 or granzyme B (GZMB), which converts non-inflammatory apoptosis to pyroptosis or promotes granzyme-mediated pyroptosis, respectively (PubMed : 27281216, PubMed : 28459430, PubMed : 32188940, PubMed : 33852854, PubMed : 35594856). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, allowing the release of mature interleukins (IL1B and IL16) and triggering pyroptosis (PubMed : 28459430, PubMed : 32188940, PubMed : 33852854, PubMed : 35594856). Binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed : 28459430). Cleavage by CASP3 switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis (PubMed : 27281216, PubMed : 28459430, PubMed : 32188940). Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents (PubMed : 28045099). Exhibits bactericidal activity (PubMed : 27281216). Cleavage by GZMB promotes tumor suppressor activity by triggering robust anti-tumor immunity (PubMed : 21522185, PubMed : 32188940). Suppresses tumors by mediating granzyme-mediated pyroptosis in target cells of natural killer (NK) cells : cleavage by granzyme B (GZMB), delivered to target cells from NK-cells, triggers pyroptosis of tumor cells and tumor suppression (PubMed : 31953257, PubMed : 32188940). May play a role in the p53/TP53-regulated cellular response to DNA damage (PubMed : 16897187).. Gasdermin-E, N-terminal. (Microbial infection) Pore-forming protein, which promotes maternal placental pyroptosis in response to Zika virus infection, contributing to adverse fetal outcomes.

See full target information GSDME

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Publications (285)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:411 PubMed41039578

2025

A novel role of liquid plasma (LP) induced RONS triggers the endoplasmic reticulum stress response and is associated with GSDME-mediated pyroptosis in anaplastic thyroid cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Eun Jong Ji,Se Hyun Yeou,Sung Un Kang,Chul-Ho Kim

Signal transduction and targeted therapy 10:310 PubMed40998785

2025

Reprogramming of cancer metabolism via photoresponsive nano-PROTAC enhances pyroptosis-mediated immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Byeongmin Park,Jiwoong Choi,Jae-Hyeon Lee,Yelee Kim,Woohyeong Lee,Ansoo Lee,In-Cheol Sun,Hong Yeol Yoon,Yongju Kim,Sun Hwa Kim,Yoosoo Yang,Kwangmeyung Kim,Jooho Park,Man Kyu Shim

Bioactive materials 54:614-630 PubMed40980508

2025

Activatable companion theranostics for dual-modality imaging-escorted pyroptosis-propelled synergistic cancer therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Yilin Wan,Yurong Liu,Weihua Wen,Ting He,Chunying Li,Guohua Wang,Lijun Jin,Meng Li,Yumeng Wu,Rong Wen,Yifan Zhang,Lian-Hua Fu,Jing Lin,Peng Huang,Daxiang Cui

PLoS pathogens 21:e1013509 PubMed40982560

2025

The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.

Applications

Unspecified application

Species

Unspecified reactive species

Qingping Lan,Xiaolin Zhang,Yifan Sun,Jing Yang,Xiaojuan Li,Ersheng Kuang

International journal of molecular medicine 56: PubMed40937577

2025

CDC5L binds to ELAVL1 to inhibit pyroptosis in hepatocellular carcinoma through the Caspase 3/GSDME signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Liang,Zhongcheng Zhu,Yangshuo Tang,Shuhua Zhou,Moyan Xiao,Xuejun Gong,Ke Ye

Frontiers in pharmacology 16:1584376 PubMed40894196

2025

FGFC1 overcomes Ara-C resistance in acute myeloid leukemia by inducing apoptosis and pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohui Hu,Zhijian Li,Rui Zhou,Bing Zhang,Ruoxian Wang,Tongtong Li,Jiangcheng Chang,Wenhui Wu,Ning Liu

PLoS neglected tropical diseases 19:e0013443 PubMed40892762

2025

PANoptosis-mediated mechanisms underlying AST elevation in Talaromyces marneffei infection.

Applications

Unspecified application

Species

Unspecified reactive species

Wudi Wei,Baili Zhan,Lixiang Chen,Gang Wang,Xiuli Bao,Xiaotao He,Meng Zhang,Xiaoting Xie,Weihong Huang,Zhiman Xie,Junjun Jiang,Hao Liang,Li Ye

Frontiers in pharmacology 16:1575106 PubMed40860880

2025

Hydrogen gas (H) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction-associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Chen,Kangrong Wang,Wenhai Guo,Chengqin Lu,Wenting Suo,Qiuling Li,Yao Deng,Xinling Chen,Min Dai,Xiaodong Zhang,Jiean Xu,Wen Su,Shuangling Yang,Hongzhi Yang,Fuman Yan,Haimei Liu,Yaxing Zhang

Science advances 11:eadw2756 PubMed40834068

2025

RPA1 protects DNA damage-induced PANoptosis in limb development.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Yin,Shuanglin Peng,Zhong Zhang,Shuang Jiang,Xuan Li,Denghao Huang,Yang Li,Jian Zhou,Jingang Xiao,Ling Ye,Yuxin Yin,Quan Yuan

Frontiers in immunology 16:1616715 PubMed40761801

2025

Development of Z- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaochun Tan,Jiani Yang,Yanheng Li,Kairong Wan,Sicong Feng,Xishang Jing,Zhenyun Xie,Lifang Zhang,Wenshu Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Flow Cytometry (Intracellular) - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Flow Cytometry (Intracellular) - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Immunoprecipitation - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

Western blot - Anti-DFNA5/GSDME antibody [EPR19859] - N-terminal (AB215191)

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Key facts

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Carrier free

Reacts with

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Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

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Primary Antibodies

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Primary Antibodies

Primary Antibodies

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Shipped at conditions

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