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AB136103

Anti-DGKB antibody

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(1 Publication)

Rabbit Polyclonal DGKB antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DGKB.

View Alternative Names

DAGK2, KIAA0718, DGKB, Diacylglycerol kinase beta, DAG kinase beta, 90 kDa diacylglycerol kinase, Diglyceride kinase beta, DGK-beta

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human DGKB. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6T7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab136103 was affinity purified from rabbit antiserum by immunogenic peptide affinity chromatography
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DGKB or Diacylglycerol Kinase Beta is a member of the diacylglycerol kinase family which plays an important role in the metabolism of diacylglycerol (DAG) into phosphatidic acid. DGKB exhibits a molecular weight of approximately 92 kDa. This protein localizes primarily in the brain but also shows expression in various other tissues including the liver and heart. Human cells use DGKB to regulate intracellular levels of diacylglycerol a lipid signaling molecule involved in numerous cellular processes.
Biological function summary

DGKB contributes to critical cellular signaling and functions within membrane-associated complexes. It participates in the regulation of diverse cellular functions such as growth differentiation and apoptosis by converting DAG into phosphatidic acid a precursor for biosynthesis of other lipids. DGKB therefore modulates signal transduction pathways mediated through protein kinase C among other signaling proteins. Its activity maintains a balance in lipid signaling essential for normal cell physiology.

Pathways

DGKB takes part in lipid signaling pathways and interplays with the phosphoinositide signaling pathways. It plays a role by regulating DAG's availability thereby influencing protein kinase C activity which affects cellular responses to external stimuli. DGKB closely interacts with proteins such as phosphatidylinositol-45-bisphosphate through its catalytic activity in these pathways impacting physiological functions like cell motility and mitosis.

DGKB has been implicated in psychiatric and neurological conditions. Its altered activity or expression may contribute to the pathogenesis of conditions such as bipolar disorder and Alzheimer's disease. Studies also link DGKB to protein kinase C-related disorders highlighting its potential as a therapeutic target. This relationship underlines the importance of DGKB in maintaining normal brain function and its potential involvement in neuropsychiatric disease pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed : 11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).. Isoform 2. Does not associate with membranes but has a diacylglycerol kinase activity.
See full target information DGKB
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 11: PubMed35262486

2022

Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of , and mRNAs in developing mouse neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

Kawssar Harb,Melanie Richter,Nagammal Neelagandan,Elia Magrinelli,Hend Harfoush,Katrin Kuechler,Melad Henis,Irm Hermanns-Borgmeyer,Froylan Calderon de Anda,Kent Duncan
View all publications
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Product promise

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