Anti-DGKG antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DGKG also known as diacylglycerol kinase gamma is an important enzyme that phosphorylates diacylglycerol (DAG) to produce phosphatidic acid (PA). This enzyme possesses a molecular mass of approximately 90 kDa. DGKG is expressed in many tissues with particularly high levels in brain and muscle. Its expression in these areas indicates a significant role in neuronal signaling and muscle function.

Biological function summary

DGKG influences various cellular processes by transforming diacylglycerol into phosphatidic acid. This enzymatic activity regulates the levels of DAG a critical second messenger involved in signal transduction. DGKG does not solely function on its own but is part of larger signaling complexes that mediate signal cascades. Through this involvement DGKG impacts cell growth differentiation and metabolism.

Pathways

DGKG plays a significant role in the phosphatidylinositol signaling pathway. This pathway is essential for transmitting extracellular signals to intracellular responses primarily involving protein kinase C (PKC). DGKG also interacts with proteins such as RAS and RAF kinases indicating its participation in the MAPK/ERK pathway. These interactions highlight its contribution to transmitting signals that regulate cellular proliferation and differentiation.

Associated diseases and disorders

DGKG shows associations with cancer and neurological disorders. The altered expression or function of DGKG may contribute to oncogenesis by affecting cell signaling pathways that control cell growth. Additionally its role in neuronal signaling links it to neurological conditions possibly through interactions with proteins such as PKC. DGKG's dysregulation in these contexts suggests its potential as a therapeutic target in managing these diseases.