Anti-DHRS1 Antibody [S01-9E4]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DHRS1 also known as dehydrogenase/reductase SDR family member 1 is an enzyme involved in biochemical reactions. It belongs to the short-chain dehydrogenase/reductase (SDR) family and has a mass of about 33 kDa. This enzyme participates in redox reactions specifically by catalyzing the oxidation and reduction processes involving small substrates. DHRS1 is mainly expressed in liver and kidney tissues which suggests its role in metabolic processes associated with these organs.

Biological function summary

DHRS1 plays an important role in lipid metabolism. It helps in the conversion of steroid precursors and participates in the inactivation of steroid hormones. This enzyme does not form part of a complex but interacts with other enzymes within the same family to maintain balanced metabolic functions. Its activity assists in ensuring proper physiological levels of various metabolites and hormones.

Pathways

DHRS1 integrates into the lipid metabolism and steroid hormone biosynthesis pathways. It interacts with key proteins involved in oxidative metabolism such as 11β-hydroxysteroid dehydrogenase contributing to the regulation and conversion processes within these pathways. These interactions are important in controlling the balance of metabolites and support the physiological functionality of lipids and hormones.

Associated diseases and disorders

DHRS1 is associated with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Changes in DHRS1 activity can affect lipid processing and hormone regulation leading to these metabolic conditions. It may connect to proteins like peroxisome proliferator-activated receptor gamma (PPARγ) which also influences lipid metabolism and has a role in the onset of metabolic diseases. Understanding DHRS1's interactions and alterations could provide insight into therapeutic targets for these conditions.